6BIO

Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Anticancer compound. Potent antiproliferative agent. Suppresses metastasis. Apoptosis inducer. Sustains pluripotency and self-renewal of human and mouse embryonic stem cells (ESCs) by activation of the Wnt signaling pathway. Anti-leishmanial (IC50 = 0.15 ?M). Proto-oncogene tyrosine-protein kinase receptor RET inhibitor (IC50=0.51 ?M). Inhibits HIV-1 transcription and protects against Tat induced neurotoxicity.