Description: GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3alpha/beta and CDK1-cyclinB complex. It inhibits (GSK-3alpha/beta)/CDK1/CDK5 activity with IC50 values of 5 nM/320 nM/83 nM, respectively. Target: Apoptosis, CDK, GSK-3, Tyrosine Kinases. Smiles:...

BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3alpha/beta (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A,...

Phosphoinositide-dependent kinase 1 (PDK1) inhibitor, Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor, JAK/STAT3 signaling inhibitor, Apoptosis inducer, Potent antiproliferative agent in malignant lymphoid cell.

Soluble in DMSO or ethanol. Stock solutions can be made up to 10 mM in DMSO. Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Anticancer compound. Potent antiproliferative...