5-(N,N-dimethyl)-Amiloride (hydrochloride)

Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N,N-dimethyl)-Amiloride (DMA) inhibits NHE1, NHE2, and NHE3 with Ki values of 0.02, 0.25, and 14 µM, respectively. Because NHE1 is present in dorsal root ganglion and spinal cord, DMA was investigated for its ability to reduce inflammatory pain in rat nociception behavior tests.Formal Name: 3-amino-N-(aminoiminomethyl)-6-chloro-5-(dimethylamino)-2-pyrazinecarboxamide, monohydrochloride. CAS Number: 2235-97-4. Synonyms: DMA, L-591,605, MK-685. Molecular Formula: C8H12ClN7O . HCl. Formula Weight: 294.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 231, 294, 374 nm. SMILES: CN(C)C1=NC(N)=C(C(NC(N)=N)=O)N=C1Cl.Cl. InChi Code: InChI=1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12,/h1-2H3,(H2,10,14)(H4,11,12,15,17),1H. InChi Key: IIUPTHVVXMBJMQ-UHFFFAOYSA-N.