5'-Deoxy-5'-methylthioadenosine-d3

5'-Deoxy-5'-methylthioadenosine-d3 (MTA-d3) is intended for use as an internal standard for the quantification of MTA (Cay-15593) by GC- or LC-MS. MTA is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine. This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 µM for A1, A2A, A2B, and A3, respectively). At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 µM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.Formal Name: 7-[5-S-(methyl-d3)-5-thio-beta-D-ribofuranosyl]-7H-purin-6-amine. CAS Number: 174838-38-1. Synonyms: 5'-S-Methylthioadenosine-d3, MTA-d3, Vitamin L2-d3. Molecular Formula: C11H12D3N5O3S. Formula Weight: 300.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: slightly soluble, Methanol: slightly soluble. SMILES: O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](CSC([2H])([2H])[2H])[C@H]1O. InChi Code: InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1/i1D3. InChi Key: WUUGFSXJNOTRMR-YZLHILBGSA-N.