(±)-4-hydroxy Propranolol (hydrochloride)

(±)-4-hydroxy Propranolol is an active metabolite of the beta-adrenergic receptor antagonist (±)-propranolol (Cay-23349). It is formed from propranolol by the cytochrome P450 (CYP) isoform CYP2D6. (±)-4-hydroxy Propranolol decreases tachycardia and vasodepression induced by the beta1- and beta2-adrenergic receptor agonist isoproterenol (Cay-15592) in cats (EC50 = 54 µg/kg). It increases heart rate in rats depleted of catecholamines by the monocarboxylate transporter 1 (MCT1) and MCT2 inhibitor syrosingopine (Cay-36402) when administered at doses of 10 and 80 µg/kg. (±)-4-hydroxy Propranolol decreases heart rate, myocardial contractility, and cardiac output in dogs in a dose-dependent manner. It also reduces superoxide-induced lipid peroxidation in isolated rat hepatic microsomes (IC50 = 1.1 µM) and prevents superoxide-induced depletion of glutathione (GSH) levels in bovine aortic endothelial cells (BAECs, EC50 = 1.2 µM).Formal Name: 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-1-naphthalenol, monohydrochloride. CAS Number: 14133-90-5. Molecular Formula: C16H21NO3 . HCl. Formula Weight: 311.8. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 208, 243, 319 nm. SMILES: OC1=CC=C(OCC(O)CNC(C)C)C2=C1C=CC=C2.Cl. InChi Code: InChI=1S/C16H21NO3.ClH/c1-11(2)17-9-12(18)10-20-16-8-7-15(19)13-5-3-4-6-14(13)16,/h3-8,11-12,17-19H,9-10H2,1-2H3,1H. InChi Key: ROUJENUXWIFONU-UHFFFAOYSA-N.