4-hydroxy Atorvastatin (calcium salt)

4-hydroxy Atorvastatin is a metabolite of atorvastatin (Cay-10493), an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin.Formal Name: 2-(4-fluorophenyl)-betaR,deltaR-dihydroxy-4-[[(4-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-phenyl-1H-pyrrole-1-heptanoic acid, hemicalcium salt. CAS Number: 265989-44-4. Synonyms: p-hydroxy Atorvastatin, para-hydroxy Atorvastatin. Molecular Formula: C33H34FN2O6 . 1/2Ca. Formula Weight: 593.7. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 15 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 253 nm. SMILES: O=C(C1=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C2=CC=C(F)C=C2)=C1C3=CC=CC=C3)NC4=CC=C(O)C=C4.O=C(C5=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC([O-])=O)C(C6=CC=C(F)C=C6)=C5C7=CC=CC=C7)NC8=CC=C(O)C=C8.[Ca+2]. InChi Code: InChI=1S/2C33H35FN2O6.Ca/c2*1-20(2)31-30(33(42)35-24-12-14-25(37)15-13-24)29(21-6-4-3-5-7-21)32(22-8-10-23(34)11-9-22)36(31)17-16-26(38)18-27(39)19-28(40)41,/h2*3-15,20,26-27,37-39H,16-19H2,1-2H3,(H,35,42)(H,40,41),/q,,+2/p-2/t2*26-,27-,/m11./s1. InChi Key: PYIWEMFVBXVPDU-MNSAWQCASA-L.