4-desmethoxy Omeprazole

4-desmethoxy Omeprazole is a potential impurity found in commercial omeprazole and esomeprazole magnesium preparations. Omeprazole (Cay-14880) is a selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 1.1 µM). It is a racemic mixture of two enantiomers, (S)-omeprazole (esomeprazole magnesium, Cay-17326) and (R)-omeprazole (Cay-18874), which are prodrugs of the active sulfonamide which is formed by acid-stimulated conversion. Both enantiomers are extensively metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4.Formal Name: 2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-6-methoxy-1H-benzimidazole. CAS Number: 110374-16-8. Synonyms: 4-desmethoxy OMEP, 4-desmethoxy OMP, 4-desmethoxy OMZ, Esomeprazol Magnesium Impurity B, Omeprazole EP Impurity B. Molecular Formula: C16H17N3O2S. Formula Weight: 315.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 302 nm. SMILES: COC1=CC=C2C(N=C(S(CC3=C(C)C=C(C)C=N3)=O)N2)=C1. InChi Code: InChI=1S/C16H17N3O2S/c1-10-6-11(2)15(17-8-10)9-22(20)16-18-13-5-4-12(21-3)7-14(13)19-16/h4-8H,9H2,1-3H3,(H,18,19). InChi Key: ZMXZYNHJPJEPAE-UHFFFAOYSA-N.