3-O-methyl Tolcapone

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Item number	Size	Manual	Delivery time	Price
Cay45833-10	10 mg	-	6 - 10 business days*	40.00€
Cay45833-25	25 mg	-	6 - 10 business days*	89.00€
Cay45833-50	50 mg	-	6 - 10 business days*	166.00€
Cay45833-100	100 mg	-	6 - 10 business days*	273.00€

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3-O-methyl Tolcapone is a stabilizer of transthyretin (TTR) and a metabolite of tolcapone... more

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Product information "3-O-methyl Tolcapone"

3-O-methyl Tolcapone is a stabilizer of transthyretin (TTR) and a metabolite of tolcapone (Cay-20768). Unlike tolcapone, 3-O-methyl tolcapone does not inhibit catechol-O-methyltransferase (COMT) and is not cytotoxic to SH-SY5Y or HepG2 cells (EC50s = 226.3 and 262.3 µM, respectively). 3-O-methyl Tolcapone (1 and 10 µM) stabilizes TTR in isolated human plasma and binds to TTR in a cell-free assay (Kd = 33 nM).. SMILES: O=C(C1=CC(OC)=C(C([N+]([O-])=O)=C1)O)C2=CC=C(C)C=C2. InChi Code: InChI=1S/C15H13NO5/c1-9-3-5-10(6-4-9)14(17)11-7-12(16(19)20)15(18)13(8-11)21-2/h3-8,18H,1-2H3. InChi Key: VCNSNEJUGBEWTA-UHFFFAOYSA-N

Keywords:	3-OMT, Ro 40-7591, (4-hydroxy-3-methoxy-5-nitrophenyl)(4-methylphenyl)-methanone
Supplier:	Cayman Chemical
Supplier-Nr:	45833

Properties

Application:	TTR stabilizer, tolcapone metabolite
MW:	287.27 D
Formula:	C15H13NO5
Purity:	>98%
Format:	Crystalline Solid

Database Information

CAS :	134612-80-9\| Matching products
KEGG ID :	K20731 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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