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3-O-methyl Tolcapone
Item number: Cay45833-10
3-O-methyl Tolcapone is a stabilizer of transthyretin (TTR) and a metabolite of tolcapone (Cay-20768). Unlike tolcapone, 3-O-methyl tolcapone does not inhibit catechol-O-methyltransferase (COMT) and is not cytotoxic to SH-SY5Y or HepG2 cells (EC50s = 226.3 and 262.3 µM, respectively). 3-O-methyl Tolcapone (1 and 10...
| Keywords: | 3-OMT, Ro 40-7591, (4-hydroxy-3-methoxy-5-nitrophenyl)(4-methylphenyl)-methanone |
| Application: | TTR stabilizer, tolcapone metabolite |
| CAS | 134612-80-9 |
| MW: | 287.27 D |
From 40.00€
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3-O-Methyltolcapone
Item number: TGM-T10119-100mg
Description: 3-O-Methyltolcapone (Ro 40-7591), a metabolite of Tolcapone, is a potent COMT inhibitor that crosses the blood-brain barrier and can be used for the treatment of Parkinson's disease. Target: Transferase. Smiles: COc1cc(cc(c1O)[N+]([O-])=O)C(=O)c1ccc(C)cc1. References: Jorga K, et al. Metabolism and...
| Keywords: | Ro 40-7591 |
| CAS | 134612-80-9 |
| MW: | 287.27 D |
2,371.00€
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