3,8'-Biapigenin

3,8'-Biapigenin is a polyketide synthase-derived biflavonoid that has been found in Hypericum and has diverse biological activities. It inhibits protein tyrosine phosphatase 1B (PTP1B, IC50 = 4.5 µM) and stimulates glucose uptake in 3T3-L1 adipocyte cells when used at concentrations of 5 and 10 µM. 3,8'-Biapigenin inhibits the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, and CYP1A2 (Kis = 0.038, 0.32, and 0.95 µM, respectively). It reverses cell death induced by kainate and NMDA in isolated rat embryonic hippocampal neurons when used at a concentration of 10 µM. 3,8'-Biapigenin (8 mg/kg) decreases carrageenan-induced paw edema and protects against gastric lesions induced by indomethacin (Cay-70270) in rats.Formal Name: 5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-[3,8'-bi-4H-1-benzopyran]-4,4'-dione. CAS Number: 101140-06-1. Synonyms: I3,II8-Biapigenin, 3,8"-Biapigenin. Molecular Formula: C30H18O10. Formula Weight: 538.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Alcohol: soluble. SMILES: O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3C4=C(C5=CC=C(O)C=C5)OC6=C(C(O)=CC(O)=C6)C4=O. InChi Code: InChI=1S/C30H18O10/c31-15-5-1-13(2-6-15)22-12-21(37)24-19(35)11-20(36)26(30(24)39-22)27-28(38)25-18(34)9-17(33)10-23(25)40-29(27)14-3-7-16(32)8-4-14/h1-12,31-36H. InChi Key: IQAMTZLKUHMPPE-UHFFFAOYSA-N. Origin: Plant/Unidentified sp..