3,5,6,7,8,3',4'-Heptamethoxyflavone

3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF) is a polymethoxyflavone that has been found in C. reticulata and has diverse biological activities. It inhibits the efflux of Hoechst 33342 (Cay-15547) by breast cancer resistance protein (BCRP) and rhodamine 123 (Cay-16672) by P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), in MDCK cells expressing the human transporters (IC50s = 1.4 and 31 µM, respectively). HMF (50, 100, and 200 µg/ml) prevents UVB-induced decreases in type I procollagen in primary human dermal fibroblast neonatal (HDFn) cells. It inhibits the proliferation of B16 melanoma 4A5, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cells (IC50s = 38, 29, and 9 µM, respectively). HMF (50 mg/kg) prevents corticosterone-induced increases in immobility time in the forced swim test in mice.Formal Name: 2-(3,4-dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-H-1-benzopyran-4-one. CAS Number: 1178-24-1. Synonyms: HMF, NSC 618928. Molecular Formula: C22H24O9. Formula Weight: 432.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: O=C1C(OC)=C(C2=CC(OC)=C(OC)C=C2)OC3=C(C(OC)=C(C(OC)=C13)OC)OC. InChi Code: InChI=1S/C22H24O9/c1-24-12-9-8-11(10-13(12)25-2)16-19(27-4)15(23)14-17(26-3)20(28-5)22(30-7)21(29-6)18(14)31-16/h8-10H,1-7H3. InChi Key: SSXJHQZOHUYEGD-UHFFFAOYSA-N. Origin: Plant/Citrus sp..