193 products were found matching "K05658"!

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White)....

Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells. It is a substrate for the efflux pump P-glycoprotein (P-gp, also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp. As P-gp is expressed on a population of stem...

Tariquidar is an anthranilic acid derivative that binds to P-glycoprotein (Kd = 5.1 nM) and inhibits transport activity. It inhibits transport of vinblastine (Cay-11762) and paclitaxel (Cay-10461) in multidrug resistant CHrB30 cells, increasing the steady state accumulation to non-P-glycoprotein-expressing multidrug...

Protein function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. [The UniProt Consortium]

Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities. It reduces LPS- and IFN-gamma-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM. Nobiletin...

Zosuquidar is a modulator of P-glycoprotein (P-gp, Ki = 59 nM). It restores the sensitivity of P-gp-expressing cancer cells to vinblastine (Cay-11762), doxorubicin (Cay-15007), etoposide (Cay-12092), and paclitaxel (Cay-10461) when used at 0.1 µM. It less potently inhibits cytochrome P450 (CYP) isoforms CYP3A,...

Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. P Glycoprotein, also called MDR1, P-GP, and PGY1, is a protein that in humans is encoded by the ABCB1 gene. It is mapped to 7q21.12. It is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular...

Elacridar is a dual inhibitor of P-glycoprotein (MRP-1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2). It maximally inhibits P-glycoprotein in isolated human peripheral blood leukocytes at 200 nM. Elacridar blocks the activity of P-glycoprotein at the blood-brain barrier, altering the pharmacokinetics of...

C6 NBD Lactosylceramide (d18:1/6:0) is a biologically active derivative of lactosylceramides (d18:1/acyl mixture) (Cay-16983) that is tagged with a fluorescent C-6 nitrobenzoxadiazole (C-6 NBD, Cay-18871) group. C6 NBD Lactosylceramide (d18:1/6:0) has been used to study the effects of P-glycoprotein inhibition in...

Description: Rhodamine 123 is a fluorescent dye (lambdaex=503 nm, lambdaem=527 nm). Target: Others. Smiles: COC(C1=CC=CC=C1C2=C3C=CC(N)=CC3=[O+]C4=C2C=CC(N)=C4)=O.[Cl-]. References: M. Huang, et al. Mitochondrial Inner Membrane Electrophysiology Assessed by Rhodamine-123 Transport and Fluorescence. Ann Biomed Eng....

White to off-white lyophilized powder. Soluble in DMSO or 100% ethanol (25mg/ml). Efficient inhibitor of P-glycoprotein (Pgp, MDR-1) function through direct interactions. By inhibiting MDR-1, active compounds remain in the cytoplasm longer and allowing them to be more effective within the cell, Reversing agent for...