3,4-Dihydroxyphenylacetic Acid

3,4-dihydroxyphenylacetic acid (DOPAC) is a metabolite of dopamine (Cay-21992) formed through deamination by monoamine oxidase (MAO). DOPAC is further metabolized by catechol-O-methyltransferase (COMT) to form homovanillic acid, and DOPAC levels are increased 5- to 6-fold compared to wild-type in the nucleus accumbens, striatum, and prefrontal cortex of COMT knockout mice. DOPAC oxidation is catalyzed by alpha-synuclein and oxidized DOPAC binds to monomeric alpha-synuclein preventing fibrillation. In vivo, foot shock stress increases DOPAC levels relative to control by approximately 45% in the prefrontal cortex and by 15% in the olfactory tubercles and ventral tegmental area (VTA) in rats.Formal Name: 3,4-dihydroxy-benzeneacetic acid. CAS Number: 102-32-9. Synonyms: DOPAC, NSC 73191. Molecular Formula: C8H8O4. Formula Weight: 168.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 280 nm. SMILES: OC1=C(O)C=CC(CC(O)=O)=C1. InChi Code: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12). InChi Key: CFFZDZCDUFSOFZ-UHFFFAOYSA-N.