3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

Description: 3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) is a non-nucleotide inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1, Ki = 50 µM).1,2 It also inhibits urease (IC50 = 84.53 µM for the Jack bean enzyme).3. Target: Others. Smiles: O=C1OC=2C=CC=CC2C(O)=C1C(C=3C=CC=CC3Cl)C=4C(=O)OC=5C=CC=CC5C4O. References: Choudhary, M.I., Fatima, N., Khan, K.M., et al. New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities. Bioorg. Med. Chem. 14(23), 8066-8072 (2006).