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Product information "2-Methylthioadenosine diphosphate (sodium salt)"
2-Methylthioadenosine diphosphate (2-MeSADP) is an agonist of purinergic P2Y receptors with EC50s of 5.13 and 0.89 nM for human recombinant P2Y1 and P2Y12 receptors, respectively. It also acts as an agonist at rat P2Y1 and P2Y12 and mouse P2Y13 receptors (EC50s = 0.58, 0.89, and 6.2 nM, respectively). It induces platelet aggregation and inhibits cyclic AMP accumulation in platelet-rich plasma stimulated by prostaglandin E1 (PGE1, Cay-13010) more potently than ADP (Cay-21121, Cay-16778).Formal Name: 2-(methylthio)-adenosine 5'-(trihydrogen diphosphate), trisodium salt. CAS Number: 475193-31-8. Synonyms: 2-MeSADP, 2-methylthio ADP. Molecular Formula: C11H14N5O10P2S . 3Na. Formula Weight: 539.2. Purity: >98%. Formulation: (Request formulation change), A solution in water. Solubility: PBS (pH 7.2): 10 mg/ml, Water: soluble. lambdamax: 236, 275 nm. SMILES: O[C@H]1[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@H](COP(OP([O-])([O-])=O)([O-])=O)[C@H]1O.[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C11H17N5O10P2S.3Na/c1-29-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(25-10)2-24-28(22,23)26-27(19,20)21,,,/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H2,12,14,15)(H2,19,20,21),,,/q,3*+1/p-3/t4-,6-,7-,10-,,,/m1.../s1. InChi Key: DYNGCIHMNWOBSU-MSQVLRTGSA-K.
Keywords:
2-MeSADP, 2-Methylthio-ADP, 2-(methylthio)-adenosine 5'-(trihydrogen diphosphate), trisodium salt
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