2-chloro-3-Deazaadenosine

Adenosine receptors are a family of G protein-coupled receptors that display distinct patterns of ligand binding and tissue distribution, regulating a variety of physiological functions. 2-chloro-3-Deazaadenosine is a stable analog of adenosine that acts as an agonist for adenosine receptors (Ki = 0.3, 0.08, 25.5, and 1.9 µM for A1, A2A, A2B, and A3 receptors, respectively). It can block neurotransmitter release by activating A1 receptors or inhibit neurotransmission by activating A2A receptors. 2-chloro-3-Deazaadenosine blocks seizures by stimulating A1 receptors.Formal Name: 6-chloro-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine. CAS Number: 40656-71-1. Synonyms: 6-Amino-2-chloropurine riboside, 2-CADO, NSC 158900. Molecular Formula: C11H13ClN4O4. Formula Weight: 300.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2.5 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 274 nm. SMILES: OC[C@H]1O[C@@H](N2C(C=C(Cl)N=C3N)=C3N=C2)[C@H](O)[C@@H]1O3N=C2)C(O)C1O. InChi Code: InChI=1S/C11H13ClN4O4/c12-6-1-4-7(10(13)15-6)14-3-16(4)11-9(19)8(18)5(2-17)20-11/h1,3,5,8-9,11,17-19H,2H2,(H2,13,15)/t5-,8-,9-,11-/m1/s1. InChi Key: LIDWXUGNGGWNEU-MGUDNFKCSA-N.