2',3'-Dideoxythymidine-5'-O-triphosphate (sodium salt)

2',3'-Dideoxythymidine-5'-O-triphosphate (ddTTP) is a reverse transcriptase inhibitor (Kis = 40 and 25 nM for the visna virus and HIV-1 enzymes, respectively). It also inhibits DNA polymerase gamma (Ki = 400 nM for the bovine enzyme). ddTTP has been used to terminate chain extension produced by the Taq polymerase in PCR assays.Formal Name: ((2S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl triphosphate. Synonyms: ddTTP. Molecular Formula: C10H13N2O13P3 . 4Na. Formula Weight: 554.1. Purity: >95%. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: O=C(N(C=C1C)[C@H]2CC[C@@H](COP([O-])(OP(OP([O-])([O-])=O)([O-])=O)=O)O2)NC1=O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C10H17N2O13P3.4Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17,,,,/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17),,,,/q,4*+1/p-4/t7-,8+,,,,/m0..../s1. InChi Key: OKYHUQUPPJASGU-JWQBCWJNSA-J.