2',3'-Dideoxyguanosine-5'-O-triphosphate (sodium salt)

2',3'-Dideoxyguanosine-5'-O-triphosphate (ddGTP) is a reverse transcriptase inhibitor (Kis = 13 and 6.7 nM for the visna virus and HIV-1 enzymes, respectively). ddGTP has been used in the synthesis of oligonucleotides containing a terminal ddG that are resistant to cleavage by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exonuclease. ddGTP has also been used to terminate chain extension produced by the Taq polymerase in PCR assays.Formal Name: 2',3'-dideoxy-guanosine 5'-(tetrahydrogen triphosphate), tetrasodium salt. Synonyms: ddGTP. Molecular Formula: C10H12N5O12P3 . 4Na. Formula Weight: 579.1. Purity: >95%. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: [O-]P(OP(OC[C@@H]1CC[C@H](N2C(NC(N)=NC3=O)=C3N=C2)O1)([O-])=O)(OP([O-])([O-])=O)=O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C10H16N5O12P3.4Na/c11-10-13-8-7(9(16)14-10)12-4-15(8)6-2-1-5(25-6)3-24-29(20,21)27-30(22,23)26-28(17,18)19,,,,/h4-6H,1-3H2,(H,20,21)(H,22,23)(H2,17,18,19)(H3,11,13,14,16),,,,/q,4*+1/p-4/t5-,6+,,,,/m0..../s1. InChi Key: AIFBYZLQROBIRU-YPNYOHIOSA-J.