2',3'-Dideoxycytidine-5'-O-triphosphate (sodium salt)

2',3'-Dideoxycytidine-5'-O-triphosphate is an active metabolite of the reverse transcriptase inhibitor zalcitabine (Cay-16019). It is an inhibitor of DNA polymerases beta and gamma (Kis = 1.32 and 0.034 µM, respectively, for the human enzymes). 2',3'-Dideoxycytidine-5'-O-triphosphate (1 mM) inhibits HIV-1 replication in isolated human erythrocytes. Intraperitoneal administration of 2',3'-dideoxycytidine-5'-O-triphosphate-loaded erythrocytes reduces spleen and lymph node weight, limits increases in IgG levels, and decreases mediastinal lymph node swelling in a mouse model of LP-BM5 leukemic retrovirus infection-induced immunodeficiency.Formal Name: 2',3'-dideoxy-cytidine 5'-(tetrahydrogen triphosphate), tetrasodium salt. Synonyms: ddCTP, Dideoxycytidine 5'-triphosphate, Zalcitabine 5'-triphosphate. Molecular Formula: C9H12N3O12P3 . 4Na. Formula Weight: 539.1. Purity: >95%. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: O=C1N=C(N)C=CN1[C@H]2CC[C@@H](COP([O-])(OP(OP([O-])([O-])=O)([O-])=O)=O)O2.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C9H16N3O12P3.4Na/c10-7-3-4-12(9(13)11-7)8-2-1-6(22-8)5-21-26(17,18)24-27(19,20)23-25(14,15)16,,,,/h3-4,6,8H,1-2,5H2,(H,17,18)(H,19,20)(H2,10,11,13)(H2,14,15,16),,,,/q,4*+1/p-4/t6-,8+,,,,/m0..../s1. InChi Key: XXEMRIJGTWHLIS-DAKHTTANSA-J.