2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt)

2',3'-Dideoxyadenosine-5'-O-triphosphate is a reverse transcriptase inhibitor (Kis = 20 and 37 nM for the HIV and visna virus enzymes, respectively) and an active metabolite of 2',3'-dideoxyadenosine (ddA, Cay-36662) and didanosine (ddI, Cay-23715). It is formed from ddI via a 2',3'-dideoxyAMP intermediate by phosphoribosyl pyrophosphate synthase (PRS). It inhibits DNA polymerase isolated from mouse Ehrlich ascites tumor cells in the presence of ATP or GDP (Kis = 60 and 18 µM, respectively). 2',3'-Dideoxyadenosine-5'-O-triphosphate and other dideoxynucleoside 5'-triphosphates are commonly used to terminate chain extension by Taq polymerases in PCR assays.Formal Name: 2',3'-dideoxy-adenosine 5'-(tetrahydrogen triphosphate), tetrasodium salt. CAS Number: 99827-72-2. Synonyms: ddATP, Dideoxyadenosine-5'-triphosphate. Molecular Formula: C10H12N5O11P3 . 4Na. Formula Weight: 563.1. Purity: >95%. Formulation: (Request formulation change), A solution in water. Solubility: Water: Soluble. SMILES: NC1=C(N=C2)C(N2[C@H]3CC[C@@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)O3)=NC=N1.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C10H16N5O11P3.4Na/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18,,,,/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18),,,,/q,4*+1/p-4/t6-,7+,,,,/m0..../s1. InChi Key: HIQMRNGZTRSRFK-NOTWHITJSA-J.