17-DMAG

Geldanamycin (Cay-13355) is a potent inhibitor of Hsp90 that has poor water solubility. 17-DMAG is a water-soluble derivative of geldanamycin which potently inhibits Hsp90 (IC50 = 24 nM) and has excellent bioavailability and tissue distribution in animals. Like other Hsp90 inhibitors, 17-DMAG has diverse anti-tumor actions and has potential in treating certain types of cancer. This compound also suppresses inflammation by interfering with signaling through the NF-kappaB pathway. 17-DMAG also ameliorates high fat diet-induced renal failure in a mouse model of diabetes.Formal Name: 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-geldanamycin. CAS Number: 467214-20-6. Synonyms: Alvespimycin, KOS-1022, NSC 707545. Molecular Formula: C32H48N4O8. Formula Weight: 616.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 13 mg/ml, Ethanol: 2 mg/ml. lambdamax: 220, 332, 529 nm. SMILES: O=C(C(NCCN(C)C)=C1C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@@H]2OC(N)=O)C=C(NC(/C(C)=C/C=C\[C@@H]2OC)=O)C1=O. InChi Code: InChI=1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25. InChi Key: KUFRQPKVAWMTJO-LMZWQJSESA-N.