1-Deoxymannojirimycin (hydrochloride)

1-Deoxymannojirimycin is a specific inhibitor of class I alpha-1,2-mannosidase (IC50 = 0.02 µM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi and for targeting misfolded proteins for translocation out of the endoplasmic reticulum and degradation by the proteasome. By inhibiting alpha-1,2-mannosidase activity, this compound generates N-linked oligosaccharides with high mannose content, preventing misfolded protein degradation. This compound has been used for studies on glycoprotein processing and as a model for the development of anticancer and antiviral therapies.Formal Name: 2R-(hydroxymethyl)-3R,4R,5R-piperidinetriol, monohydrochloride. CAS Number: 73465-43-7. Molecular Formula: C6H13NO4 . HCl. Formula Weight: 199.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)NC1.Cl. InChi Code: InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3,/h3-11H,1-2H2,1H/t3-,4-,5-,6-,/m1./s1. InChi Key: ZJIHMALTJRDNQI-MVNLRXSJSA-N.