Sulfanilamide

Sulfanilamide is a sulfonamide antibiotic. It is bacteriostatic against Streptococcus when used at a concentration of 20 µg/ml and inhibits the growth of 106 clinical isolates of Gonococcus at 0.01% v/v. Sulfanilamide reduces plasma levels of Streptococcus in infected rabbits. It is an inhibitor of carbonic anhydrase II (CAII) and CAIX (Kis = 294 and 300 nM, respectively, for the human enzymes). It is selective for CAII and CAIX over CAI and CAIV (Kis = 3000 and >10,000 nM, respectively, for the bovine and human enzymes). Sulfanilamide inhibits the growth of S. haemolyticus and E. coli when used at a concentration of 300 µM. Formulations containing sulfanilamide have been used in the topical treatment of vaginal fungal infections.Formal Name: 4-amino-benzenesulfonamide. CAS Number: 63-74-1. Synonyms: 4-Aminobenzenesulfonamide, p-Aminobenzenesulfonamide, NSC 7618, Ro 1-3354. Molecular Formula: C6H8N2O2S. Formula Weight: 172.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble, Water: Slightly Soluble. lambdamax: 264 nm. SMILES: NC1=CC=C(S(N)(=O)=O)C=C1. InChi Code: InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10). InChi Key: FDDDEECHVMSUSB-UHFFFAOYSA-N.