Puromycin (hydrochloride)

Puromycin (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13884-25 25 mg -

5 - 10 business days*

Cay13884-50 50 mg -

5 - 10 business days*

Cay13884-100 100 mg -

5 - 10 business days*

Cay13884-500 500 mg -

5 - 10 business days*

Puromycin is an aminonucleoside antibiotic, derived from S. alboniger, that blocks protein... more
Product information "Puromycin (hydrochloride)"
Puromycin is an aminonucleoside antibiotic, derived from S. alboniger, that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains. A portion of the puromycin molecule resembles the 3' end of aminoacylated tRNA. It enters the A site of the ribosome and attaches to the growing polypeptide chain at the peptidyl transferase center, causing the formation of a puromycylated nascent chain and premature chain release. The 3' position contains an amide linkage instead of the normal ester linkage of tRNA, making it much more resistant to hydrolysis and halting the activity of the ribosome. These properties of puromycin have been exploited in assays for peptide-bond formation and elongation and also the antibiotic is often used as selective agent in cell culture systems. Formal Name: 3'-[[2S-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine, dihydrochloride. CAS Number: 58-58-2. Synonyms: CL 13,900, CL 16,536, NSC 3055, PDH. Molecular Formula: C22H29N7O5 . 2HCl. Formula Weight: 544.4. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 13 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 217, 276 nm. SMILES: O[C@H]([C@@H]1NC([C@@H](N)CC2=CC=C(OC)C=C2)=O)[C@@H](O[C@@H]1CO)N3C(N=CN=C4N(C)C)=C4N=C3.Cl.Cl. InChi Code: InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12,,/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32),2*1H/t14-,15+,16+,18+,22+,,/m0../s1. InChi Key: MKSVFGKWZLUTTO-FZFAUISWSA-N.
Keywords: CL 13,900, CL 16,536, NSC 3055, PDH, 3'-[[2S-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine, dihydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 13884


Application: Aminonucleosid antibiotic
MW: 544.4 D
Formula: C22H29N7O5 . 2HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 58-58-2| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302
P Phrases: P264, P270, P301+310, P330, P501
Our products are for laboratory research use only: Not for administration to humans!
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