Puromycin is a derivative of the glomerular epithelial cell toxin puromycin aminonucleoside (Cay-15509) and an inhibitor of protein synthesis that has been found in S. alboniger. Puromycin is structurally similar to the amino acid-bearing end of tRNA, which allows it to enter the ribosome during protein synthesis,...

Aminonucleoside antibiotic - Protein synthesis inhibitor. Disrupts peptide transfer on ribosomes (acting as an acyl-tRNA analog) causing premature chain termination during translation. Translational inhibitor in prokaryotic and eukaryotic cells in both in vitro and in vivo systems - Inhibits the transport of...

Puromycin allows the selection of cells expressing the puromycin-N-acetyl-transferase (pac). The expression of pac gene confers puromycin resistance to transfected cells. Puromycin selection works for gram-positive bacteria and animal cells. Fungi and gram-negative bacteria are resistant due to low permeability of...

A solution (10mg/ml, 0.2uM sterile filtered) of Puromycin Dihydrochloride in deionized water. Suitable for cell culture applications. Source: Streptomyces alboniger, Synonyms: (3'-[a-Amino-p-methoxyhydrocinnamamido]-3'deoxy-N,N-dimethyladenosine) dihydrochloride, Achromycin, Stillomycin, Stylomycin, Antibiotic CL...

Antibiotic substance produced by the soil actinomycete Streptomyces alboniger. It induces apoptosis in cells by interfering with RNA function which is followed by inhibition of protein formation. Puromycin substantially enhaces the cytotoxicity of fludarabine against chronic lymphocytic leukemia.