PA-824

PA-824 is an anti-tuberculosis (anti-TB) agent that is activated intracellularly via deazaflavin-dependent nitroreductase (Ddn) metabolism into a desnitro metabolite that kills M. tuberculosis by releasing reactive nitrogen species (RNS), including nitric oxide. It is active against replicating and non-replicating M. tuberculosis but exhibits little or no activity against M. avium, M. smegmatis, M. chelonae, and M. fortuitum. In vitro, it inhibits growth of susceptible and mono- and multi-drug resistant M. tuberculosis clinical isolates (MICs = 0.015-5 µg/ml). In vivo, PA-824 (100 mg/kg per day) decreases luminescence in the lung to background levels after 60 days of treatment in a mouse model of systemic infection with a reporter strain of M. tuberculosis. It also decreases M. tuberculosis burden in the lung and spleen in an aerosol challenged guinea pig model of TB when administered at a dose of 40 mg/kg per day for 30 days.Formal Name: (6S)-6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine. CAS Number: 187235-37-6. Synonyms: (S)-PA-824. Molecular Formula: C14H12F3N3O5. Formula Weight: 359.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 5 mg/ml. lambdamax: 324 nm. SMILES: FC(F)(F)OC1=CC=C(CO[C@@H]2COC3=NC([N+]([O-])=O)=CN3C2)C=C1. InChi Code: InChI=1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1. InChi Key: ZLHZLMOSPGACSZ-NSHDSACASA-N.