Manumycin A

Manumycin A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010497-1 1 mg -

6 - 10 business days*

113.00€
Cay10010497-5 5 mg -

6 - 10 business days*

423.00€
 
Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase)... more
Product information "Manumycin A"
Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. It exhibits significant antitumor activity against Ki-ras-activated solid tumors in mice at a dose of 6.3 mg/kg. Manymycin A inhibits IkappaB kinase (IKK), independent of FTase inhibition, in an number of cells types with effective concentrations of 2-10 µM. In ApoE-deficient mice, Manumycin A treatment for 22 weeks at 5 mg/kg reduced aortic fatty streak lesion size to 43% of vehicle-treated animals, indicating FTase inhibition as a potential target for prevention or treatment of atherosclerosis. Formal Name: N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5--heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2E,4E,6R-trimethyl,2,4-decadienamide. CAS Number: 52665-74-4. Synonyms: NSC 622141, UCF 1C. Molecular Formula: C31H38N2O7. Formula Weight: 550.7. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 279, 318 nm. SMILES: CCCC[C@@H](C)/C=C(\C)/C=C(/C)\C(=O)NC1=C[C@@](O)(/C=C/C=C\C=C/C(=O)NC2=C(O)CCC2=O)[C@@H]2O[C@@H]2C1=O. InChi Code: InChI=1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-. InChi Key: TWWQHCKLTXDWBD-MVTGTTCWSA-N.
Keywords: NSC 622141, UCF 1C, N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5--heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2E,4E,6R-trimethyl,2,4-decadienamide
Supplier: Cayman Chemical
Supplier-Nr: 10010497

Properties

Application: FTase inhibitor
MW: 550.7 D
Formula: C31H38N2O7
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 52665-74-4| Find alternatives
KEGG ID : K05954 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302+312, H319
P Phrases: , P264, P280, P305+351+338, P337+313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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