Mafenide (hydrochloride)

A sulfonamide antibiotic, active against clinical isolates of S. pyogenes, MSSA, MRSA, Enterococcus, Enterobacteriaceae, and Gram-negative bacilli from burn patients in an agar well diffusion assay (mean zone of inhibition = 24-37 mm) but not in a broth dilution assay with MIC values ranging from 250->5,000 µg/ml, active against clinical isolates of K. pneumoniae that produce ESBL, P. aeruginosa, and A. baumannii-calcoaceticus from burn patients in an agar well diffusion assay (mean zones of inhibition = 23.5, 28.9, and 25.8 mm, respectively) but not in a broth dilution assay (mean MICs = 1,024 µg/ml for all), decreases mortality in a rat model of burn wounds seeded with rat virulent P. aeruginosa, inhibits human CAI and CAII (Kis = 41.91 and 0.612 µM, respectively)