Leptomycin A

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
LKT-L1760.1	1 mg		-	-	3 - 8 business days*		374.00€
LKT-L1760.5	5 mg		-	-	3 - 8 business days*		1,497.00€

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Leptomycin is a polyketide antibiotic initially produced by Streptomyces. Leptomycin exhibits... more

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Product information "Leptomycin A"

Leptomycin is a polyketide antibiotic initially produced by Streptomyces. Leptomycin exhibits anticancer and antifungal activity. Leptomycin inhibits CRM1, preventing nuclear export of proteins. In lung cancer cells, leptomycin induces G1 phase cell cycle arrest, in cervical carcinoma cells, leptomycin increases activation of p53, inducing apoptosis. SMILES: CC1C=CC(=O)OC1C=CC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C

Keywords:	Jildamycin, NSC 369326, (2E,10E,12E,16E,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
Supplier:	LKT Laboratories
Supplier-Nr:	L1760