Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A inhibits Rev translocation, though less potently than leptomycin B (Cay-10004976) with IC50 values of 0.8 and 0.1 nM, respectively after...

Leptomycin is a polyketide antibiotic initially produced by Streptomyces. Leptomycin exhibits anticancer and antifungal activity. Leptomycin inhibits CRM1, preventing nuclear export of proteins. In lung cancer cells, leptomycin induces G1 phase cell cycle arrest, in cervical carcinoma cells, leptomycin increases...