Ceforanide

Ceforanide is a cephalosporin antibiotic. It is active against the Gram-positive bacteria S. pyogenes, S. pneumoniae, V. streptococci, S. aureus, and S. epidermidis (MICs = 0.5, 0.2-0.5, 2, 8, and 6.2 µg/ml, respectively), as well as the Gram-negative bacteria E. coli, P. mirabilis, and K. pneumoniae (MIC50s = 1.6, 0.8, and 1.6 µg/ml, respectively). In vivo, ceforanide (30 mg/kg) reduces the number of colony forming units (CFUs) in vegetations and increases survival in a rabbit model of S. aureus-induced endocarditis. Formulations containing ceforanide have been used in the treatment of bacterial infections.Formal Name: (6R,7R)-7-[[2-[2-(aminomethyl)phenyl]acetyl]amino]-3-[[[1-(carboxymethyl)-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid. CAS Number: 60925-61-3. Synonyms: BL-S 786. Molecular Formula: C20H21N7O6S2. Formula Weight: 519.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O=C(N[C@H]1[C@](SCC(CSC2=NN=NN2CC(O)=O)=C3C(O)=O)([H])N3C1=O)CC4=C(CN)C=CC=C4. InChi Code: InChI=1S/C20H21N7O6S2/c21-6-11-4-2-1-3-10(11)5-13(28)22-15-17(31)27-16(19(32)33)12(8-34-18(15)27)9-35-20-23-24-25-26(20)7-14(29)30/h1-4,15,18H,5-9,21H2,(H,22,28)(H,29,30)(H,32,33)/t15-,18-/m1/s1. InChi Key: SLAYUXIURFNXPG-CRAIPNDOSA-N.