Ceforanide is a cephalosporin antibiotic. It is active against the Gram-positive bacteria S. pyogenes, S. pneumoniae, V. streptococci, S. aureus, and S. epidermidis (MICs = 0.5, 0.2-0.5, 2, 8, and 6.2 µg/ml, respectively), as well as the Gram-negative bacteria E. coli, P. mirabilis, and K. pneumoniae (MIC50s = 1.6,...

Description: Ceforanide is a second-generation cephalosporin antibiotic with bactericidal activity. Ceforanide causes inhibition of bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan...