Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010332-500 500 µg -

3 - 10 business days*

Cay10010332-1 1 mg -

3 - 10 business days*

Cay10010332-5 5 mg -

3 - 10 business days*

Cay10010332-10 10 mg -

3 - 10 business days*

The lipid messenger ceramide is converted to glucosylceramide by glucosylceramide synthase (GCS).... more
Product information "AMP-Deoxynojirimycin"
The lipid messenger ceramide is converted to glucosylceramide by glucosylceramide synthase (GCS). In the reverse direction, non-lysosomal glucosylceramidase (GCase), also known as beta-glucosidase 2 (BGD), cleaves the glucosyl moiety from glucosylceramide, liberating ceramide, which can be converted into sphingomyelin. AMP-deoxynojirimycin (AMP-dNM) is a hydrophobic derivative of dNM. It potently inhibits BGD (IC50 = 0.3 nM), less potently antagonizes GCS (IC50 = 25 nM), but only poorly inhibits other GCase isoforms. AMP-dNM has been shown to strongly suppress inflammation in a murine model of hapten-induced colitis, enhance insulin sensitivity in murine and rat models of insulin resistance, and induce sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells. Formal Name: 2R-(hydroxymethyl)-1-[5-(tricyclo[,7]dec-1-ylmethoxy)pentyl]-3R,4R,5S-piperidinetriol. CAS Number: 216758-20-2. Synonyms: Adamantane-pentyl-dNM, AMP-dNM, N-(5-adamantane-1-yl-methoxy-pentyl)-Deoxynojirimycin. Molecular Formula: C22H39NO5. Formula Weight: 397.6. Purity: >95%. Formulation: A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. SMILES: OC[C@H]1N(CCCCCOCC23CC4CC(CC(C4)C3)C2)C[C@H](O)[C@@H](O)[C@@H]1O. InChi Code: InChI=1S/C22H39NO5/c24-13-18-20(26)21(27)19(25)12-23(18)4-2-1-3-5-28-14-22-9-15-6-16(10-22)8-17(7-15)11-22/h15-21,24-27H,1-14H2/t15-,16+,17-,18-,19+,20-,21-,22?/m1/s1. InChi Key: XVYLNHVEAOOEGI-OIPNBASOSA-N.
Keywords: Adamantane-pentyl-dNM, AMP-dNM, N-(5-adamantane-1-yl-methoxy-pentyl)-Deoxynojirimycin, 2R-(hydroxymethyl)-1-[5-(tricyclo[,7]dec-1-ylmethoxy)pentyl]-3R,4R,5S-piperidinetriol
Supplier: Cayman Chemical
Supplier-Nr: 10010332


Application: Glucosylceramide synthase inhibitor
MW: 397.6 D
Formula: C22H39NO5
Purity: >95%
Format: Solution

Database Information

CAS : 216758-20-2| Find alternatives
KEGG ID : K00720 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225
P Phrases: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
Our products are for laboratory research use only: Not for administration to humans!
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