- Search results for K00720
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24 products were found matching "K00720"!
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Item number: Cay17236-5
DL-threo-PPMP is a ceramide analog and an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 70, 41, and 62% in MDCK cell homogenates, mouse liver microsomes, and mouse brain homogenates, respectively, when used at a concentration of 20 µM. DL-threo-PPMP also inhibits sphingomyelin...
Keywords: | DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol,... |
Application: | Glucosylceramide synthase inhibitor |
CAS | 139974-41-7 |
MW: | 511.2 D |
From 54.00€
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Item number: ELK-ELK5132.96
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human UGCG. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human UGCG. Next,...
Keywords: | GCS, GLCT-1, Glucosylceramide synthase, Glycosylceramide synthase, Ceramide glucosyltransferase, UDP-glucose ceramide... |
Application: | ELISA |
Species reactivity: | human |
From 303.00€
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Item number: Cay21065-1
NB-DNJ is an iminosugar that inhibits UDP-glucose ceramide glucosyltransferase and beta-glucosidase 2 (IC50s = 32 and 81 µM, respectively, for the rat recombinant enzymes). It also increases the activity of wild-type acid beta-glucosidase, as well as the S364R, N370S, V15M, or M123T mutants, in COS-7 cells...
Keywords: | Miglustat, NB-DNJ, 1-butyl-2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol, monohydrochloride |
Application: | Glucosylceramide synthase inhibitor |
CAS | 210110-90-0 |
MW: | 255.7 D |
From 50.00€
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Item number: Cay21487-10
Eliglustat is an inhibitor of glucosylceramide synthase (IC50 = 40 nM for inhibition of glucosylceramide production in K562 cells). It is selective for glucosylceramide synthase over alpha-glucosidase I and II, alpha-1,6-glucosidase, lysosomal glucocerebrosidase, non-lysosomal glucosylceramidase, sucrase, and...
Keywords: | Genz-112638, N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-octanamide,... |
Application: | Glucosylceramide synthase inhibitor |
CAS | 928659-70-5 |
MW: | 479.6 D |
From 43.00€
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Item number: Cay10010332-1
The lipid messenger ceramide is converted to glucosylceramide by glucosylceramide synthase (GCS). In the reverse direction, non-lysosomal glucosylceramidase (GCase), also known as beta-glucosidase 2 (BGD), cleaves the glucosyl moiety from glucosylceramide, liberating ceramide, which can be converted into...
Keywords: | Adamantane-pentyl-dNM, AMP-dNM, N-(5-adamantane-1-yl-methoxy-pentyl)-Deoxynojirimycin,... |
Application: | Glucosylceramide synthase inhibitor |
CAS | 216758-20-2 |
MW: | 397.6 D |
From 58.00€
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Item number: Cay32878-250
Ibiglustat is an inhibitor of glucosylceramide (GlcCer) synthase. Dietary administration of ibiglustat (0.03% w/w) reduces globotriaosylceramide (Gb3) and lyso-Gb3 accumulation in a variety of tissues, including the kidney, heart, and brain, in the Gla-/- mouse model of Fabry disease. It reduces the latency to paw...
Keywords: | Genz-682452, GZ/SAR402671, Venglustat, N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]-carbamic acid,... |
Application: | GlcCer synthase (ceramide glucosyltransferase) inhibitor |
CAS | 1401090-53-6 |
MW: | 389.5 D |
From 172.00€
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Item number: Cay10178-10
(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP (Cay-62595). (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 50% when used at a concentration of 5 µM in an enzyme assay. (+)-D-threo-PDMP is the active component of...
Keywords: | D-PDMP, N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride |
Application: | Glucosylceramide (GlyCer) synthetase inhibitor |
CAS | 139889-62-6 |
MW: | 427 D |
628.00€
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Item number: Cay23206-500
Glucosylceramides are formed by the tethering of glucose to a ceramide by glucosylceramides synthase. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species, where they comprise 5-30% of total lipids in the plant plasma membrane, and in...
Keywords: | GluCers (buttermilk), Glucocerebrosides (buttermilk) |
MW: | 784.2 D |
From 85.00€
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Item number: Cay25850-10
Glucosylceramides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species, where they comprise 5-30% of total lipids in the plant plasma membrane, and in...
Keywords: | GluCers (soy) |
Application: | Glucocerebroside mixture |
CAS | 497155-61-0 |
MW: | 714 D |
From 149.00€
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Item number: Cay28500-100
Genz-123346 is a glucosylceramide synthase inhibitor (IC50 = 14 nM). It reduces hepatic levels of glucosylceramide and triglycerides as well as blood levels of alanine aminotransferase (ALT), hemoglobin A1c, and non-fasting glucose in ob/ob mice when administered at a dose of 120 mg/kg per day. Genz-123346 (125...
Keywords: | N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-nonanamide |
Application: | Glucosylceramide synthase (ceramide glucosyltransferase) inhibitor |
CAS | 491833-30-8 |
MW: | 418.6 D |
From 175.00€
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Item number: G-HUFI01598.96
Application: | ELISA |
Species reactivity: | human |
641.00€
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Item number: E-AB-14100.120
Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in...
Keywords: | Anti-GCS, Anti-UGCG, Anti-GLCT-1, EC=2.4.1.80, Anti-Glucosylceramide synthase, Anti-Ceramide glucosyltransferase,... |
Application: | IHC, ELISA |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
From 71.00€
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