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Taurolithocholic Acid (sodium salt) (CRM)
Item number: Cay45114-1
Taurolithocholic acid (sodium salt) (CRM) (Cay45114) is a certified reference material categorized as a conjugated bile acid. It is a taurine-conjugated form of the secondary bile acid lithocholic acid (Cay44907, Cay20253). Serum levels of taurolithocholic acid increase approximately 5-fold within two hours during...
| Keywords: | NSC 681057, Sodium Taurolithocholate, TLCA, 2-[[(3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl] amino]-ethanesulfonic acid,... |
| Application: | Certified reference material, conjugated bile acid |
| CAS | 6042-32-6 |
| MW: | 505.69 D |
124.00€
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Noscapine (hydrochloride) (CRM)
Item number: Cay45140-1
Noscapine (hydrochloride) (CRM) (Cay45140) is a certified reference material categorized as an opiate alkaloid and antitussive. It has been found in P. somniferum, the opium poppy, and unlike codeine and morphine, noscapine lacks sedative and hypnotic properties. This product is intended for analytical forensic...
| Keywords: | Narcotine, Opianine,... |
| Application: | Certified reference material, opiate alkaloid, antitussive |
| CAS | 912-60-7 |
| MW: | 449.88 D |
166.00€
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MTX-211
Item number: Cay45142-1
MTX-211 is a dual inhibitor of PI3Kalpha and EGFR (IC50s = <100 nM for both). It reduces viability of 5637, EJ, and UM-UC-3 bladder cancer cells (IC50s = 1.075, 1.514, and 2.189 µM, respectively), an effect that can be partially inhibited by glutathione (GSH). MTX-211 also induces apoptosis, increases the levels of...
| Keywords: | N-[2-chloro-5-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolinyl]-3-pyridinyl]-methanesulfonamide |
| Application: | PI3Kalpha/EGFR dual inhibitor |
| CAS | 1952236-05-3 |
| MW: | 478.32 D |
From 55.00€
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BATCP
Item number: Cay45143-1
BATCP is a fluorogenic substrate for histone deacetylase 6 (HDAC6) and sirtuin 1 (SIRT1). Upon enzymatic cleavage by HDAC6 or SIRT1, 7-amino-4-trifluoromethylcoumarin (AFC) is released and its fluorescence can be used to quantify HDAC6 or SIRT1 activity. AFC displays excitation/emission maxima of 400/505 nm,...
| Keywords: | N-[(1S)-5-(acetylamino)-1-[[[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]amino]carbonyl]pentyl]-carbamic acid,... |
| Application: | HDAC6/SIRT1 fluorogenic substrate |
| CAS | 787549-23-9 |
| MW: | 499.49 D |
From 83.00€
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Hyodeoxycholic Acid (CRM)
Item number: Cay45166-1
Hyodeoxycholic acid (CRM) (Cay45166) is a certified reference material categorized as a secondary bile acid. Serum levels of hyodeoxycholic acid are increased in patients with Crohn's disease or ulcerative colitis. Hyodeoxycholic acid serum levels are also increased after Roux-en-Y gastric bypass (RYGB) surgery in...
| Keywords: | HDCA, NSC 60672, alpha-Hyodeoxycholic Acid, (5beta)-3alpha,6alpha-dihydroxy-cholan-24-oic acid |
| Application: | Certified reference material, secondary bile acid |
| CAS | 83-49-8 |
| MW: | 392.58 D |
124.00€
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1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol (sodium...
Item number: Cay45187-10
1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol is a glycerophospholipid formed by phospholipase D in the presence of ethanol. It has commonly been used as a biomarker of alcohol consumption and can be detected in the blood for approximately one month.. SMILES:...
| Keywords: | 16:0-18:1 Phosphatidylethanol-IsoPure, 1-Hexadecanoyl-2-(9(Z)-octadecenoyl)-sn-glycero-3-phosphoethanol,... |
| Application: | Phospholipid, alcohol consumption biomarker |
| CAS | 322647-55-2 |
| MW: | 724.98 D |
From 68.00€
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5-Carboxamidotryptamine (hydrochloride)
Item number: Cay45295-10
5-Carboxyamidotryptamine is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT7. It binds to the 5-HT1D receptor in postmortem human cortical tissue (IC50s = 1.82 and 2,041 nM for the high- and low-affinity binding sites, respectively) and the 5-HT7 receptor in HEK293 cells expressing 5-HT7 (Ki =...
| Keywords: | 5-CT, 3-(2-aminoethyl)-1H-indole-5-carboxamide, hydrochloride |
| Application: | 5-HT1/5-HT7 receptor agonist |
| CAS | 467451-77-0 |
| MW: | 203.25 D |
From 208.00€
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Lumateperone
Item number: Cay45296-100
Lumateperone is an atypical antipsychotic. It selectively binds to the serotonin (5-HT) receptor subtype 5-HT2A over 5-HT1A and 5-HT2C receptors (Kis = 0.54, 1,480, and 173 nM, respectively). Lumateperone also binds to dopamine D1, D2, and D4 receptors (Kis = 52, 32, and 108 nM, respectively), alpha1A- and...
| Keywords: | ITI-007, ITI-722,... |
| Application: | Atypical antipsychotic |
| CAS | 313368-91-1 |
| MW: | 393.51 D |
From 64.00€
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GSK690
Item number: Cay45336-10
GSK690 is a lysine-specific demethylase 1 (LSD1) inhibitor (IC50 = 0.09 µM in a cell-free assay). It is selective for LSD1 over monoamine oxidase A (MAO-A, IC50 = >200 µM). GSK690 inhibits LSD1 activity in THP-1 acute myeloid leukemia cells (IC50 = 1.4 µM). It potentiates reductions in viability of SJCRH30...
| Keywords: | 4-[2-(4-methylphenyl)-5-[(3R)-3-pyrrolidinylmethoxy]-3-pyridinyl]-benzonitrile |
| Application: | LSD1 inhibitor |
| CAS | 2101305-84-2 |
| MW: | 369.47 D |
From 97.00€
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2-Furoic Acid
Item number: Cay45449-100
2-Furoic acid is a synthetic and biosynthetic intermediate. It is a synthetic intermediate in the conversion of lignocellulose-derived furural into 2,5-furandicarboxylic acid, a compound used in the synthesis of pharmaceuticals, pesticides, and polymers. 2-Furoic acid has been used as an organic ligand in...
| Keywords: | 2-Carboxyfuran, Furan-2-carboxylic Acid, NSC 58965, NSC 8842, Pyromucic Acid, 2-furancarboxylic acid |
| Application: | Synthetic/biosynthetic intermediate |
| CAS | 88-14-2 |
| MW: | 112.08 D |
From 35.00€
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Alternaric Acid
Item number: Cay45460-1
Alternaric acid is a phytotoxin that has been found in A. solani. It inhibits germination and root development of carrot, mustard, radish, and tomato seeds when used at a concentration of 5 µg/ml and induces necrotic lesions in potato shoots. Alternaric acid (0.005-100 µg/ml) is also active against several plant...
| Keywords: | 4,5-dideoxy-2-C-[(1E)-7-[(6R)-5,6-dihydro-4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl]-4-methylene-7-oxo-1... |
| Application: | Phytotoxin |
| CAS | 10088-62-7 |
| MW: | 410.46 D |
From 319.00€
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Shearinine A
Item number: Cay45475-1
Shearinine A is an indole diterpene that has been found in P. janthinellum and has diverse biological activities. It inhibits protein tyrosine phosphatase 1B (PTP1B), T cell protein tyrosine phosphatase (TCPTP), Src homology region 2 domain-containing phosphatase 1 (SHP-1), and SHP-2 (IC50s = 1.3, 3.8, 2.9, and 4...
| Keywords: | (+)-Shearinine A,... |
| Application: | Bioactive indole diterpene fungal metabolite |
| CAS | 163136-24-1 |
| MW: | 583.77 D |
From 235.00€
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