No results were found for the filter!
Paltusotine
Item number: Cay42041-10
An SST2 agonist, selectively inhibits cAMP production in cells expressing SST2 over cells expressing SST1, SST3, SST4, or SST5 (EC50s = 25, >1,000, >1,000, >1,000, and >1,000 nM, respectively), reduces GHRH-stimulated growth hormone release in rats at 3, 10, and 30 mg/kg, reduces plasma levels of IGF-1 in beagle...
| Keywords: | CRN00808, 3-[4-(4-amino-1-piperidinyl)-3-(3,5-difluorophenyl)-6-quinolinyl]-2-hydroxy-benzonitrile |
| Application: | SST2 agonist |
| CAS | 2172870-89-0 |
| MW: | 456.5 D |
From 421.00€
*
BI-87G3
Item number: Cay42045-1
A JNK1 inhibitor (IC50 = 1.804 µM), selective for JNK1 over p38alpha MAPK, Akt, furin, and lethal factor (IC50s = >100, >100, >100, and >50 µM, respectively), inhibits TNF-alpha-induced JNK1 phosphorylation in HeLa cells (IC50 = ~15 µM). Formulation: A solid. InChI:...
| Keywords: | c-Jun N-terminal Kinase Inhibitor XI, JNK Inhibitor XI, 2-[(5-nitro-2-thiazolyl)thio]-benzothiazole |
| Application: | JNK1 inhibitor |
| CAS | 2207-44-5 |
| MW: | 295.4 D |
From 40.00€
*
KEA1-97
Item number: Cay42049-10
An inhibitor of the protein-protein interaction between Trx and caspase-3, binds to K72 of Trx and inhibits DCT-alkyne labeling of recombinant Trx (IC50 = 10 µM), inhibits the interaction between thioredoxin and caspase-3 in a cell-free assay at 100 µM, reduces survival and proliferation of and induces apoptosis in...
| Keywords: | 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-amine |
| Application: | Trx-caspase-3 protein-protein interaction inhibitor |
| CAS | 2138882-71-8 |
| MW: | 335.16 D |
From 70.00€
*
CFT-7455
Item number: Cay42053-1
A cereblon ligand 1-containing degrader of IKZF1 and IKZF3, reduces levels of IKZF1 and IKZF3 in NCI H929 cells at 0.1 nM, decreases the growth of NCI H929 cells (GI50 = 0.0743 nM), reduces tumor volume in an RPMI-8226 plasmocytoma mouse xenograft model at 30 or 100 µg/kg per day. Formulation: A solid. InChI:...
| Keywords: | Cemsidomide, 3S-[6-[[4-(4-morpholinylmethyl)phenyl]methyl]-2-oxobenz[cd]indol-1(2H)-yl]-2,6-piperidinedione |
| Application: | Cereblon ligand 1-containing IKZF1 / IKZF3 degrader |
| CAS | 2504235-67-8 |
| MW: | 469.53 D |
From 110.00€
*
AZ 13705339
Item number: Cay42087-10
A PAK1 inhibitor (IC50 = 0.33 nM), selective for PAK1 over a panel of 117 kinases at 100 nM, binds to PAK1 and PAK2 (Kd = 0.28 and 0.32 nM, respectively), inhibits S. enterica infection in HAP1 cells at 10 µM, inhibits cell death induced by an antibody targeting Siglec-8 in IL-5-stimulated primary human eosinophils...
| Keywords: | 2-[[[2-[[3-(ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylpheny... |
| Application: | PAK1 (p21-activated kinase 1) inhibitor |
| CAS | 2016806-57-6 |
| MW: | 629.8 D |
From 116.00€
*
GAPDH Inhibitor Compound F8
Item number: Cay42090-1
A covalent inhibitor of GAPDH (IC50 = 39.31 µM), decreases viability of, and glucose metabolism in, HEK293 cells in a concentration-dependent manner. Formulation: A solid. InChI: InChI=1S/C20H18N2O5/c1-3-13(7-15(5-1)23-9-17-11-25-17)19-21-22-20(27-19)14-4-2-6-16(8-14)24-10-18-12-26-18/h1-8,17-18H,9-12H2. InChIKey:...
| Keywords: | 2,5-bis[3-(2-oxiranylmethoxy)phenyl]-1,3,4-oxadiazole |
| Application: | GAPDH covalent inhibitor |
| CAS | 252212-58-1 |
| MW: | 366.37 D |
From 55.00€
*
Martinostat
Item number: Cay42100-10
An HDAC inhibitor (IC50s = 0.3, 2, 0.6, and 4.1 nM for HDAC1, -2, -3, and -6, respectively), selective for these HDACs over HDAC4, -5, -7, -8, and -9 (IC50s = 1,970, 352, >20,000, >15,000, and >15,000 nM, respectively), reduces H3K9ac and H4K12ac in primary mouse neuronal cells (EC50s = 100 nM for both)....
| Keywords: | N-hydroxy-3-[4-[[methyl(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]methyl]phenyl]-2E-propenamide |
| Application: | HDAC inhibitor |
| CAS | 1629052-58-9 |
| MW: | 354.5 D |
From 153.00€
*
GSK467
Item number: Cay42103-1
A JARID1B inhibitor (IC50 = 0.02-0.1 µM), selective for JARID1B over KMD2, -3, -4, and -5 (IC50s = 1-10 µM). Formulation: A solid. InChI: InChI=1S/C17H13N5O2/c23-16-14-6-7-18-9-15(14)20-17(21-16)24-13-8-19-22(11-13)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H,20,21,23). InChIKey: ZTYRLXUTLYBVHH-UHFFFAOYSA-N. SMILES:...
| Keywords: | 2-[[1-(phenylmethyl)-1H-pyrazol-4-yl]oxy]- pyrido[3,4-d]pyrimidin-4(3H)-one |
| Application: | JARID1B (KDM5B) inhibitor |
| CAS | 1628332-52-4 |
| MW: | 319.3 D |
From 60.00€
*
GSK3beta Inhibitor 1
Item number: Cay42107-10
A GSK3beta inhibitor (IC50 = 4.19 nM), decreases blood glucose levels in an OGTT in a rat model of high-fat diet and STZ-induced diabetes at 50 mg/kg. Formulation: A solid. InChI: InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-. InChIKey: YKQONSWBHGBDSB-XFXZXTDPSA-N....
| Keywords: | Glycogen Synthase Kinase 3beta Inhibitor I, (3Z)-1,3-dihydro-3-(2-pyridinylmethylene)-2H-indol-2-one |
| Application: | GSK3beta inhibitor |
| CAS | 187325-53-7 |
| MW: | 222.2 D |
From 223.00€
*
A-425619
Item number: Cay42117-10
A TRPV1 antagonist, selective for TRPV1 over a panel of 83 receptors, enzymes, transporters, and ion channels at 10 µM, inhibits capsaicin-, NADA-, anandamide-, or acid-induced increases in intracellular calcium in HEK293 cells expressing human TRPV1 (IC50s = 5, 4, 3, and 2 nM, respectively), increases core body...
| Keywords: | N-5-isoquinolinyl-N'-[[4-(trifluoromethyl)phenyl]methyl]-urea |
| Application: | TRPV1 antagonist |
| CAS | 581809-67-8 |
| MW: | 345.3 D |
From 208.00€
*
D-Amino Acid Oxidase Inhibitor
Item number: Cay23894-100
An inhibitor of DAAO (IC50s = 145 and 114 nM in CHO cells expressing human and rat DAAO, respectively), selective for DAAO over a panel of 150 enzymes, receptors and ion channels (30 µM), inhibits DAAO activity in rat kidney and cerebellum in a dose- and time-dependent manner (10-200 mg/kg, i.p.), increases levels...
| Keywords: | DAAO inhibitor, 4H-thieno[3,2-b]pyrrole-5-carboxylic acid |
| Application: | DAAO inhibitor |
| CAS | 39793-31-2 |
| MW: | 167.2 D |
From 40.00€
*
Voacanga africana Ethanol Extract
Item number: Cay43250-1
A natural extract, contains a crude mixture of bioactive natural products extracted from V. africana. Formulation: A solution in methanol. InChI: . InChIKey: . SMILES:
| Keywords: | V. africana Ethanol Extract |
| Application: | Natural extract, crude mixture of bioactive natural products |
76.00€
*