KEA1-97

An inhibitor of the protein-protein interaction between Trx and caspase-3, binds to K72 of Trx and inhibits DCT-alkyne labeling of recombinant Trx (IC50 = 10 µM), inhibits the interaction between thioredoxin and caspase-3 in a cell-free assay at 100 µM, reduces survival and proliferation of and induces apoptosis in Trx-overexpressing 231MFP breast cancer cells, reduces tumor volume in a 231MFP mouse xenograft model at 5 mg/kg. Formulation: A solid. InChI: InChI=1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22). InChIKey: DUROVTLUQOYUPH-UHFFFAOYSA-N. SMILES: ClC1=NC(Cl)=NC(NC2=CC=C(C3=CC=C(F)C=C3)C=C2)=N1