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Lirafugratinib
Item number: Cay40940-1
A covalent FGFR2 inhibitor (IC50 = 0.003 µM), selective for FGFR2 over FGFR1, -3, and -4 (IC50s = 0.77, 0.26, and 15 µM, respectively), inhibits the proliferation of SNU-16 cells (IC50 = 0.002 µM), reduces intratumoral FGFR2 phosphorylation and tumor volume in an FGFR2-amplified SNU-16 gastric cancer mouse xenograft...
| Keywords: | RLY-4008,... |
| Application: | Covalent FGFR2 inhibitor |
| CAS | 2549174-42-5 |
| MW: | 509.5 D |
From 55.00€
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LGD 6972 (ammonium salt)
Item number: Cay40961-1
A GCGR antagonist, reduces glucagon-induced hyperglycemia in wild-type mice, reduces blood glucose levels in mouse models of diabetes. Formulation: A solid. InChI:...
| Keywords: | 2-[[4-[(2R)-2-[4'-(1,1-dimethylethyl)[1,1'-biphenyl]-4-yl]-3-oxo-3-[(2',4',6'-trimethyl[1,1'-biphenyl]-4-yl)amino]propyl]b... |
| Application: | GCGR antagonist |
| MW: | 719.9 D |
From 74.00€
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CVN293
Item number: Cay40983-1
A K2P13.1/THIK1 channel inhibitor (IC50 = 49 nM), selective for K2P13.1/THIK1 over K2P6.1/TWIK2 and K2P2.1/TREK-1 channels (IC50s = >30,000 nM for both), inhibits NLRP3 inflammasome-mediated IL-1ß production in LPS-stimulated primary neonatal murine microglia (IC50 = 24 nM). Formulation: A solid. InChI:...
| Keywords: | 4-[7-fluoro-1-(3-pyridazinylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine |
| Application: | K2P13.1/THIK1 channel inhibitor |
| CAS | 2815296-08-1 |
| MW: | 311.27 D |
From 105.00€
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ECC5004
Item number: Cay41324-1
A GLP-1R agonist, induces cAMP accumulation in HEK293 cells expressing human GLP-1R (EC50 = <20 nM). Formulation: A solid. InChI:...
| Keywords: | AZD 5004,... |
| Application: | GLP-1R agonist |
| CAS | 3011682-51-9 |
| MW: | 880.94 D |
299.00€
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VPS34-IN-19
Item number: Cay41357-10
An inhibitor of VPS34 (IC50 = 15 nM), selective for VPS34 over PI3Kdelta (IC50 = 802 nM) and PI3Kalpha, PI3Kbeta, and PI3Kgamma (IC50s = >802 nM for all), increases intratumoral levels of LC3-II, a marker of autophagy but does not reduce tumor volume in an RKO colon cancer mouse xenograft model at 50 mg/kg twice per...
| Keywords: | Compound 19, Vacuolar Protein Sorting 34 Inhibitor 19, VPS Inhibitor 19,... |
| Application: | VPS34 inhibitor |
| CAS | 1383716-46-8 |
| MW: | 391.5 D |
From 147.00€
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MSD-M1PAM
Item number: Cay41358-1
A positive allosteric modulator of M1 mAChRs, enhances ACh-induced calcium production in a calcium mobilization assay from 0.1-10 µM, reverses scopolamine-induced deficits in freezing behavior in mice from 1-30 mg/kg, attenuates deficits in self-ordered spatial search in cynomolgus macaques and in the object...
| Keywords: | PQCA, 1-[[4-cyano-4-(2-pyridinyl)-1-piperidinyl]methyl]-4-oxo-4H-quinolizine-3-carboxylic acid |
| Application: | Muscarinic acetylcholine receptor M1 positive allosteric modulator |
| CAS | 1144504-35-7 |
| MW: | 388.4 D |
From 80.00€
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O12-D3-I3
Item number: Cay41385-1
An ionizable cationic lipid (pKa = 6.39), has been used in the generation of LNPs for siRNA delivery in vitro and in vivo, LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter decrease viability of HepG2 cells, LNPs containing O12-D3-I3 and an...
| Keywords: | didodecyl 3,3'-((3-(2-amino-3-(1H-imidazol-4-yl)propanamido)propyl)azanediyl)dipropionate |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 692.03 D |
From 60.00€
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Dovitinib (lactate)
Item number: Cay41394-1
A multi-kinase inhibitor, inhibits FLT3, CSF1R, c-Kit, FGFR1, FGFR3, VEGFR1, -2, and -3, PDFGRalpha, and PDGFRbeta (IC50s = 1, 36, 2, 8, 9, 10, 13, 8, 27, and 210 nM, respectively), inhibits the proliferation of human multiple myeloma cell lines expressing mutant, but not wild-type, FGFR3 (IC50s = 90-550 and >2,500...
| Keywords: | CHIR258, TKI-258, 2-hydroxy-propanoic acid, compd. with... |
| Application: | Multi-kinase inhibitor |
| CAS | 852433-84-2 |
| MW: | 572.59 D |
From 45.00€
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ML-401
Item number: Cay41450-10
An EBI2 antagonist (IC50 = 1.03 nM), inhibits RS11846 cell chemotaxis (IC50 = 4.533 nM). Formulation: A solid. InChI: InChI=1S/C20H20BrClN2O/c21-18-6-1-16(2-7-18)5-10-20(25)24-13-11-23(12-14-24)15-17-3-8-19(22)9-4-17/h1-10H,11-15H2/b10-5+. InChIKey: NXTNVQJKGHAGAX-BJMVGYQFSA-N. SMILES:...
| Keywords: | (2E)-3-(4-bromophenyl)-1-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-2-propen-1-one |
| Application: | EBI2 antagonist |
| CAS | 1597489-14-9 |
| MW: | 419.74 D |
From 116.00€
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Isoleucine
Item number: Cay41562-50
A mixture of isoleucine diastereomers. Formulation: A solid. InChI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9). InChIKey: AGPKZVBTJJNPAG-UHFFFAOYSA-N. SMILES: CCC(C)C(N)C(O)=O
| Keywords: | 2-amino-3-methyl-pentanoic acid |
| Application: | Isoleucine diastereomer mixture |
| CAS | 2095501-92-9 |
| MW: | 131.2 D |
55.00€
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Fenoprofen-13C6 (sodium salt hydrate)
Item number: Cay41683-1
An internal standard for the quantification of fenoprofen by GC- or LC-MS. Formulation: A solid. InChI: InChI=1S/C15H14O3.Na.H2O/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13,,/h2-11H,1H3,(H,16,17),,1H2/q,+1,/p-1/i2+1,3+1,4+1,7+1,8+1,13+1,,. InChIKey: MUQAHZSOOWLDJC-UWTURDRMSA-M. SMILES:...
| Keywords: | a-methyl-3-(phenoxy-1,2,3,4,5,6-13C6)-benzeneacetic acid, monosodium salt, hydrate |
| Application: | GC-MS, LC-MS, internal standard, quantification, NSAID |
| CAS | 2687960-29-6 |
| MW: | 270.2 D |
809.00€
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GSK3685032
Item number: Cay41882-1
A DNMT1 inhibitor (IC50 = 0.23 µM), selective for DNMT1 over DNMT3A/3L and DNMT3B/3L and a panel of 34 methyltransferases and 369 kinases (IC50s = >10 µM for all), inhibits the proliferation of 51 hematological cancer cell lines (median IC50 = 0.64 µM), decreases overall DNA methylation and gene expression in...
| Keywords: | aR-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-benzeneacetamide |
| Application: | DNMT1 inhibitor |
| CAS | 2170140-50-6 |
| MW: | 420.54 D |
From 104.00€
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