KRAS G12D-Specific TCR Lentivirus (Clone 9c)

KRAS G12D-Specific TCR Lentivirus (Clone 9c) are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles ready to transduce nearly all types of mammalian cells, including primary and non-dividing cells. These viruses transduce cells with a TCR (T cell receptor) (clone 9c) that specifically recognizes the human antigen KRAS (Kirsten rat sarcoma virus) G12D, and in which the TCR alpha chain and beta chain are linked by P2A. The lentiviruses also transduce a puromycin selection marker (Figure 1). Mouse TCR constant regions were used in this construct to boost expression.