Rat GLP-1R/CRE Luciferase Reporter HEK293 Cell Line

Rat GLP-1R/CRE Luciferase Reporter HEK293 Cell Line is an engineered HEK293 cell line expressing firefly luciferase under the control of cAMP response element (CRE), and rat GLP-1R (Rattus norvegicus Glucagon-like peptide 1 receptor, NM_012728.2). Activation of rat GLP-1R in these cells can be monitored by measuring luciferase activity. The functionality of Rat GLP-1R/CRE Luciferase Reporter HEK293 Cell Line was validated in dose-response assays using the peptide agonists human Glucagon-like peptide 1 (7-37). Rat GLP-1R/CRE Luciferase Reporter HEK293 Cell Line is a Rattus norvegicus version of GLP-1R/CRE Luciferase Reporter HEK293 Cell Line (BPS Bioscience #78176). Figure 1. Illustration of mechanism of action in Rat GLP-1R/CRE Luciferase Reporter HEK293 Cell Line. Interested in screening and profiling inhibitors, blocking antibodies, or activators of rat GIPR without the need to purchase and license the cell line? Check out our Metabolic Diseases screening services. GLP-1R, a member of the class B family of G protein-coupled receptors (GPCRs or secretin-like receptors), is a transmembrane protein primarily found in pancreatic beta cells and brain neurons. GLP-1R is activated by the peptide hormone glucagon-like peptide 1 (GLP-1), which has two active forms, GLP-1 (7-37) and GLP-1 (7-36) amide. GLP-1R plays an important role in controlling blood sugar level by enhancing glucose-stimulated insulin secretion, glucose, lipid metabolism, and satiety. Its role in the brain seems to be in the control of appetite. Research efforts have focused on the regulation of the GLP-1R mediated signaling pathway as a therapeutic approach to type 2 diabetes (T2DM) and have resulted in the development of several GLP-1 FDA-approved agonists. In addition to their role in insulin secretion, GLP-1R agonists can also contribute to weight management, decrease the potential for cardiovascular diseases and protect beta cells. A role in tumor development in patients with T2DM is also being investigated but further studies are required to fully understand the functions of GLP-1R and its agonists.