Rat GIPR/CRE Luciferase Reporter HEK293 Cell Line

Rat GIPR/CRE Luciferase Reporter HEK293 Cell Line is an engineered HEK293 cell line expressing firefly luciferase under the control of cAMP response element (CRE), and rat GIPR (Rattus norvegicus Gastric Inhibitory Polypeptide receptor, NM_012714.2). Activation of GIPR in these cells can be monitored by measuring luciferase activity. The functionality of the Rat GIPR/CRE Luciferase Reporter HEK293 Cell Line was validated in dose-response assays using the agonist rat gastric inhibitory peptide (rat GIP). Rat GIPR/CRE Luciferase Reporter HEK293 Cell Line is a Rattus norvegicus version of GIPR/CRE Luciferase Reporter HEK293 Cell Line (BPS Bioscience #78589). Interested in screening and profiling inhibitors, blocking antibodies, or activators of rat GLP-1R without the need to purchase and license the cell line? Check out our Metabolic Diseases screening services. The gastric inhibitory polypeptide receptor (GIPR), also known as glucose-dependent insulinotropic polypeptide receptor, belongs to the Class B1 G protein-coupled receptor (GPCR) family. GIPR is primarily found in the beta-cells of the pancreas and serves as a receptor for the gastric inhibitory polypeptide (GIP) hormone. As one of the incretin hormones, GIP modulates glucose metabolism by stimulating the pancreatic beta-cells to release insulin. Since GIPR/GLP-1R heterodimerization regulates GLP-1R signaling, dual agonists that bind both GIPR and GLP-1R have shown promising clinical efficacy for treating type II diabetes mellitus (T2DM) and obesity.