CHO-K1/ADRA2B/Gqi5 Stable Cell Line

Adrenoceptors are 7-transmembrane receptors which mediate the central and peripheral actions of the neurotransmitter, noradrenaline (norepinephrine), and the hormone and neurotransmitter, adrenaline (epinephrine). Based on both pharmacological and molecular evidence, they are divided into three major types - alpha1, alpha2, and beta. The alpha2 adrenoceptors include 3 subtypes - alpha2A, alpha2B, and alpha2C - each of which couples to Gi/o protein primarily. The alpha2B adrenoceptors (ADRA2B) is expressed in the kidney, liver, brain, lung, heart, and skeletal muscle. The development of alpha2B and alpha2C knock-out mice has shown that these two subtypes are not involved in the central hypotensive response to alpha2 agonists.