Rat REN (Renin) ELISA Kit

Renin is a secreted endopeptidase that plays a crucial role in the regulation of blood pressure and salt balance through the cleavage of angiotensinogen,which is the only known physiological substrate of Renin. The 406 aa precursor includes a signal peptide (aa 1 - 23),a propeptide (aa 24 - 66),and a mature chain (aa 67 - 406). It is an aspartyl protease that cleaves angiotensinogen to form angiotensin I. Renal Renin (Renin-1) is synthesized as a 381 aa proform (aa 22 - 402). In the kidney,prorenin is proteolytically cleaved after Thr71 to generate a mature enzyme.Gene AliasRenGene ID24715Uniport IDP08424Protein AliasRenResearch AreaSignal Transduction,Cardiovascular Protein function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. [The UniProt Consortium]