135 products were found matching "K01380"!

Renin is an aspartyl protease glycoprotein, a member of the aspartic acid protease family, and a hormone. It is a single-chain polypeptide in which the N- and C-terminal portions contain an aspartate residue responsible for its catalytic activity. It is formed from prorenin, a zymogen found primarily in the...

Prorenin is the inactive precursor of renin, which is a key enzyme in the regulation of blood pressure and electrolyte balance. In renal juxtaglomerular cells, sequential cleavage of the N-terminal 20 and 46 amino acids of preprorenin produces prorenin and active renin, respectively. Renin catalyzes the conversion...

Pepstatin A is a bacteria-derived pentapeptide inhibitor of aspartic proteases. It inhibits pepsin, cathepsin D, and HIV protease (IC50s = 50s = 0.32 and 15 µM for the porcine and human enzymes, respectively). It inhibits HIV replication in infected H9 cells when used at a concentration of 100 µM and inhibits...

Protein function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. [The UniProt Consortium]

Rat, activated renin (GenBank Accession No. NM_012642), amino acids 65 ? 402 (end) with C-terminal HIS tag, MW=38.5 kDa, expressed in a HEK293 cell expression system.

The renin fluorogenic substrate consists of the normal peptide substrate for renin which has been linked to the fluorophore EDANS at one end and to a non-fluorescent quenching molecule (Dabcyl) at the other. After cleavage by renin, the product (peptide-EDANS) is brightly fluorescent and can be easily analyzed using...

Aliskiren is a nonpeptide inhibitor of renin (IC50 = 0.6 nM for the human enzyme). Aliskiren (10 and 30 mg/kg per day) reduces blood pressure and prevents albuminuria in renin-overexpressing TG(mRen-2)27 rats in a model of streptozotocin-induced diabetes. It also reduces cardiac hypertrophy and fibrosis induced by...

Renin is an enzyme that participates in the body's renin-angiotensin system (RAS) that mediates extracellular volume and arterial vasoconstriction. It regulates blood pressure and electrolyte homoeostasis. Angiotensin II constricts blood vessels leading to increased blood pressure. It also increases the secretion of...

Human Activated Renin (GenBank Accession No. NM_000537), amino acids 24 ? 406 (end) with C-terminal HIS tag, MW=43.7 kDa, expressed in a mammalian expression system.

Protein function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. [The UniProt Consortium]

Aliskiren Hydrochloride is an orally active, synthetic nonpeptide Renin inhibitor that has been shown to work as an antihypertensive.

Renin is a protease that is synthesized by the kidneys. Renin catalyzes the hydrolysis of angiotensinogen to angiotensin I, which is converted to angiotensin II, a highly potent vasoconstrictor. Renin inhibitors have been used therapeutically in the treatment of hypertension (high blood pressure). The Renin Assay...