Mouse Hsd17b3 (Testosterone 17-beta-dehydrogenase 3) ELISA Kit

ELISA Type: Competitive ELISA, Coated with Antigen. Detection Range: 31.25-2000µg/mL. Sensitivity: 18.75µg/mL. Sample Types: Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples. Protein function: Catalyzes the conversion of 17-oxosteroids to 17beta- hydroxysteroids (PubMed:32557858). Favors the reduction of androstenedione to testosterone (PubMed:32557858). Testosterone is the key androgen driving male development and function (PubMed:32190925, PubMed:32557858). Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms. Plays a role in the rate-limiting- step for the maximum level of testosterone production by the testis but does not affect basal testosterone production (PubMed:32190925, PubMed:32557858). [The UniProt Consortium]