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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| BPS-82802 | 384 rxns | - | - |
3 - 15 business days* |
827.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The MDM2-p53 Homogenous Assay Kit is designed to identify and assess the efficacy of inhibitors... more
Product information "MDM2-p53 Homogenous Assay Kit"
The MDM2-p53 Homogenous Assay Kit is designed to identify and assess the efficacy of inhibitors of MDM2 (mouse double minute 2 homolog) interaction with p53 by measuring their binding. The MDM2-p53 Homogeneous Assay Kit comes in a convenient 384-well AlphaLISA(R) format, with enough purified recombinant MDM2, p53, and buffers for 400 enzyme reactions. Figure 1: Illustration of the assay principle. MDM2 contains a GST-tag, recognized by the GSH (glutathione) donor bead, while p53 contains a FLAG-tag that binds to the AlphaLISA(TM) acceptor bead conjugated with an anti-FLAG antibody. Upon excitation of the donor bead, a singlet oxygen is generated by the donor bead, which excites the acceptor bead and emits light proportionally to the level of MDM2-p53 interaction. AlphaLISA(TM) immunoassays are a no-wash alternative to ELISAs. Need us to run inhibitor screens or profile your compounds against MDM2 binding to p53? Check out our Ubiquitination Screening Services.
| Keywords: | E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein (Hdm2), Oncoprotein Mdm2, RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2, Cellular tumor antigen p53, Tumor suppressor p53, TP53, P53, |
| Supplier: | BPS Bioscience |
| Supplier-Nr: | 82802 |
Properties
| Application: | Binding studies, screen small molecule inhibitor screening, drug discovery, HTS |
| Format: | Homog. |
Database Information
| KEGG ID : | K06643 | Matching products |
| UniProt ID : | Q00987 | Matching products |
| Gene ID : | GeneID 4193 | Matching products |
Handling & Safety
| Storage: | -80°C |
| Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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