Anti-Human DNAJB1 Antibody Pair

Product Description: DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1), a member of the DnaJ heat shock protein family (Hsp40), functions primarily as a molecular chaperone, facilitating protein folding and preventing aggregation by stimulating the ATPase activity of Hsp70 proteins. This protein is characterized by a conserved J-domain, which is essential for its interaction with Hsp70, thereby playing a critical role in cellular stress responses and maintaining proteostasis. DNAJB1 is notably implicated in fibrolamellar hepatocellular carcinoma (FL-HCC), a rare and aggressive liver cancer characterized by the oncogenic fusion of DNAJB1 with the PRKACA gene, leading to aberrant protein kinase A activity. Additionally, DNAJB1 has been associated with other diseases, including various hematologic cancers and muscular dystrophies. Protein Function: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877) [The Uniprot Consortium]