Tumor Necrosis Factor Receptor Type 2, His Tag, human recombinant (rHuTNFR2-His)

Tumor Necrosis Factor Receptor Type 2, His Tag, human recombinant (rHuTNFR2-His)
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Preis anfragen

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
97288.5 5 µg - -

1 - 10 Werktage

70,00 €
97288.20 20 µg - -

1 - 10 Werktage

180,00 €
97288.1 1 mg - -

1 - 10 Werktage

-
 
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for... mehr
Produktinformationen "Tumor Necrosis Factor Receptor Type 2, His Tag, human recombinant (rHuTNFR2-His)"

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. (www.uniprot.org) Human recombinant TNFR2 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 184 amino acids fragment (23-206) having a molecular weight of 25kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. TNFR2 belongs to the TNF-receptor superfamily. TNFR2 is receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. TNFR2 mediates the majority of the metabolic effects of TNF-alpha. In addition, knockout studies in mice propose a role for TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2 expression might have a significant role in the angiogenesis, tumor cell proliferation and metastasis of Invasive micropapillary carcinoma of the breast.

Schlagworte: Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor type II, p75, p80 TNF-alpha receptor, CD120b, Etanercept, TNF-R2, TNF-RII, TNFR-II, TNFRSF1B, TNFBR, TNFR2, TBPII, TNFR2, TNFR1B, TNFR80
Hersteller: Biomol GmbH
Hersteller-Nr: 97288.1

Eigenschaften

Anwendung: Bioassay
Konjugat: No
Exprimiert in: E.coli
Ursprungsart: Human
Reinheit: >95%
Format: Purified

Datenbank Information

KEGG ID : K05141 | Finde Alternativen
UniProt ID : P20333 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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