Produkte von Indigo Biosciences

Indigo

Indigo Biosciences, Inc. wurde im Jahr 2005 in State College, PA von Dr. Jack Vanden Heuvel und Dr. Blake Peterson gegründet. Das biowissenschaftliche Unternehmen konzentriert sich auf Produkte und Dienstleistungen im Bereich Kernrezeptoren, die eine wichtige Klasse von therapeutischen Wirkstoffzielen darstellen. Hierbei stellen quantitative Aktivitäts-Assays noch immer eine besondere Herausforderung für die Biotechnologie dar. Die beiden Gründer des Unternehmens sind international anerkannte Spezialisten auf diesem Gebiet und nutzten ihre gesammelte Expertise in der Kernrezeptorbiologie, Toxikologie, medizinischer Chemie und Molekularbiologie, um die Technologie-Plattform für diese Produkte zu entwickeln.

Mehr unter: indigobiosciences.com

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AR (human) Reporter Assay Kit
AR (human) Reporter Assay Kit

Artikelnummer: IB-IB03001

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of full-length, unmodified human androgen receptor (NR3C4), a ligand-dependent transcription factor commonly referred to as AR. INDIGO's reporter cells include the luciferase...
Schlagworte: AR, DHTR, Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.121,00 €
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RORgamma (human) Reporter Assay Kit
RORgamma (human) Reporter Assay Kit

Artikelnummer: IB-IB04001

This human RAR-related orphan receptor gamma (RORgamma) mRNA is expressed from the RORC gene in two forms via alternate usage of tissue-specific promoters. Variant 1 mRNA is expressed in numerous tissues, and encodes receptor isoform 1, referred to as RORgamma. Variant 2 mRNA comprises an alternate exon 1 that...
Schlagworte: RORC, NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, RAR-related orphan receptor C, Retinoid-related...
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.121,00 €
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ERalpha (human) Reporter Assay Kit
ERalpha (human) Reporter Assay Kit

Artikelnummer: IB-IB00401

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the full-length human estrogen receptor 1 (NR3A1), a ligand-dependent transcription factor commonly referred to as ERalpha. INDIGO's reporter cells include the luciferase reporter gene...
Schlagworte: ER, ESR, ESR1, ER-alpha, Estrogen receptor, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.121,00 €
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PXR (human) Reporter Assay Kit
PXR (human) Reporter Assay Kit

Artikelnummer: IB-IB07001

Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...
Schlagworte: SXR, PXR, NR1I2, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Steroid and xenobiotic...
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.121,00 €
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RARbeta (human) Reporter Assay Kit
RARbeta (human) Reporter Assay Kit

Artikelnummer: IB-IB02101

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, beta (NR1B2), a ligand-dependent transcription factor commonly referred to as RARB or RARbeta. INDIGO's reporter cells include the luciferase reporter...
Schlagworte: HAP, RARB, RAR-beta, RAR-epsilon, HBV-activated protein, Retinoic acid receptor beta, Nuclear receptor subfamily 1 group B...
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.121,00 €
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PPARgamma (human) Reporter Assay Kit
PPARgamma (human) Reporter Assay Kit

Artikelnummer: IB-IB00101

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor gamma (NR1C3), a ligand-dependent transcription factor commonly referred to as PPARG or PPARgamma. INDIGO's reporter cells include...
Schlagworte: NR1C3, PPARG, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, Peroxisome proliferator-activated receptor gamma
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.121,00 €
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PPARdelta (human) Reporter Assay Kit
PPARdelta (human) Reporter Assay Kit

Artikelnummer: IB-IB00121

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor delta (NR1C2), a ligand-dependent transcription factor commonly referred to as PPARD or PPARdelta. INDIGO's reporter cells include...
Schlagworte: NUCI, NUC1, NR1C2, PPARD, PPAR-beta, PPAR-delta, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member...
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.121,00 €
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RORa (Human) Reporter Assay System
RORa (Human) Reporter Assay System

Artikelnummer: IB-IB04011-32

Protein function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid,...
Schlagworte: RORA, NR1F1, Nuclear receptor ROR-alpha, Nuclear receptor RZR-alpha, RAR-related orphan receptor A, Retinoid-related...
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.121,00 €
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PPAR (human) Reporter Assays Panel
PPAR (human) Reporter Assays Panel

Artikelnummer: IB-IB00131-32P

INDIGO's panel of PPAR reporter assays utilizes non-human mammalian cells engineered to express human peroxisome proliferator-activated receptors: PPARalpha (NR1C1), PPARdelta (NR1C2), or PPARgamma (NR1C3), all ligand-dependent transcription factors that are commonly referred to as PPARalpha, PPARdelta and...
Schlagworte: PPARalpha (NR1C1), PPARdelta (NR1C2), PPARgamma (NR1C3)
Anwendung: Functional activity screening
Reaktivität: Human
1.485,00 €
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MR (human) Reporter Assay Kit
MR (human) Reporter Assay Kit

Artikelnummer: IB-IB00502

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive high-level expression of full-length, unmodified human mineralocorticoid receptor (NR3C2), a ligand-dependent transcription factor commonly referred to as MR. INDIGO's reporter cells include the luciferase...
Schlagworte: MR, MCR, NR3C2, Mineralocorticoid receptor, Nuclear receptor subfamily 3 group C member 2
Anwendung: Functional activity screening
Reaktivität: Human
2.970,00 €
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PR (human) Reporter Assay Kit
PR (human) Reporter Assay Kit

Artikelnummer: IB-IB05002

This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the full-length human progesterone receptor (NR3C3), a ligand-dependent transcription factor commonly referred to as PR. INDIGO's reporter cells include the luciferase reporter gene...
Schlagworte: PR, PGR, NR3C3, Progesterone receptor, Nuclear receptor subfamily 3 group C member 3
Anwendung: Functional activity screening
Reaktivität: Human
2.970,00 €
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ERbeta (human) Reporter Assay Kit
ERbeta (human) Reporter Assay Kit

Artikelnummer: IB-IB00411

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the full-length human estrogen receptor 2 (NR3A2), a ligand-dependent transcription factor commonly referred to as ERbeta. INDIGO's reporter cells include the luciferase reporter gene...
Schlagworte: ESR2, ESTRB, ER-beta, Estrogen receptor beta, Nuclear receptor subfamily 3 group A member 2
Anwendung: Functional activity screening
Reaktivität: Human
ab 1.121,00 €
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