Peptide

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Ac-DEVD-AFC
Ac-DEVD-AFC

Artikelnummer: ABD-13401

A fluorogenic substrate for caspase 3. The 7-amido-4-trifluoromethylcoumarin derivatives have better membrane permeability than the 7-amido-4-methylcoumarin derivatives.
Anwendung: Caspase-3 substrate
CAS 201608-14-2
112,00 €
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Ac-DEVD-AMC
Ac-DEVD-AMC

Artikelnummer: ABD-13402

A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
Anwendung: Caspase-3 substrate
CAS 169332-61-0
112,00 €
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(Z-DEVD)2-R110
(Z-DEVD)2-R110

Artikelnummer: ABD-13430

Cleavage of R110 peptides by caspases generates strongly fluorescent R110 that can be monitored fluorimetrically at 510-530 nm with excitation of 488 nm.This R110 substrate is specific for caspases 3 and 7.
Anwendung: Caspase-3 substrate, Caspase-7 substrate
112,00 €
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(Ac-PAL)2R110
(Ac-PAL)2R110

Artikelnummer: ABD-13467

The non-fluorescent R110 substrates generate the bright green fluorescent rhodamine 110 product that has Ex/Em = 494/521 nm, and can be easily detected with a FITC filter set. In general, R110 substrates are much more sensitive than the AMC-, AFC- or 4-nitroaniline-based substrates. This R110 substrate is used for...
Anwendung: Protease substrate
112,00 €
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Angiotensin II (human)
Angiotensin II (human)

Artikelnummer: Cay17150-25

Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two...
Schlagworte: 5-L-isoleucine-angiotensin II
Anwendung: Peptide hormone
CAS 4474-91-3
MW: 1046.2 D
ab 24,00 €
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3,3',5'-Triiodo-L-thyronine
3,3',5'-Triiodo-L-thyronine

Artikelnummer: Cay17598-50

3,3',5'-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRalpha and TRbeta than 3,3',5-triiodo-L-thyronine (Cay-16028) and commonly described as inactive. However, high...
Schlagworte: 3,3',5'-T3, Reverse T3, rT3, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine
Anwendung: TR Delta alpha1 activator
CAS 5817-39-0
MW: 651 D
ab 82,00 €
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Pam2CSK4 (trifluoroacetate salt)
Pam2CSK4 (trifluoroacetate salt)

Artikelnummer: Cay33338-1

Pam2CSK4 is a synthetic bacterial lipopeptide and an agonist of the toll-like receptor 2 (TLR2). It is selective for the TLR2/TLR6 heterodimer over TLR2/TLR1 (EC50s = 0.015 and 4.12 ng/ml, respectively, in reporter assays using human receptors). Pam2CSK4 increases the levels of inducible nitric oxide synthase (iNOS)...
Schlagworte: Pam2Cys-Ser-(Lys)4, S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine,...
Anwendung: Bacterial lipopeptide, TLR2 agonist
MW: 1271.8 D
ab 112,00 €
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Prosaptide TX14(A) (trifluoroacetate salt)
Prosaptide TX14(A) (trifluoroacetate salt)

Artikelnummer: Cay33935-1

Prosaptide TX14(A) is a peptide fragment of the neurotrophic factor prosaposin and an agonist of GPR37L1 and GPR37. It activates ERK signaling in HEK293T cells expressing GPR37L1 or GPR37 (EC50s = 5 and 7 nM, respectively) and inhibits forskolin-induced cAMP production in the same cells. Prosaptide TX14(A) (100 nM)...
Schlagworte: Prosaposin-derived 14-mer Peptide TX14(A),...
Anwendung: Prosaposin peptide fragment, GPR37L1 / GPR37 agonist
MW: 1579.7 D
ab 98,00 €
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Glucagon
Glucagon

Artikelnummer: Cay24204-1

Glucagon is a peptide hormone produced from proglucagon in pancreatic alpha cells that has a role in the regulation of glucose metabolism. Pulsatile application of glucagon to rat hepatocytes stimulates glucose production ex vivo. It also stimulates glucose output from perfused rat livers via increases in...
Schlagworte: glucagon (swine)
Ursprungsart: Swine
CAS 16941-32-5
MW: 3482.8 D
ab 82,00 €
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Ac-QPKK(Ac)-AMC
Ac-QPKK(Ac)-AMC

Artikelnummer: Cay30790-1

Ac-QPKK(Ac)-AMC is a fluorogenic substrate for sirtuin 1 (SIRT1), SIRT2, and SIRT3. It is selectively deacylated by SIRT1-3 over SIRT6. Upon enzymatic cleavage by SIRT1, SIRT2, or SIRT3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify SIRT1, SIRT2, and SIRT3 activity. AMC...
Schlagworte: Ac-Gln-Pro-Lys-Lys-(Ac)-7-amino-4-methylcoumarin, Ac-Gln-Pro-Lys-Lys-(Ac)-AMC, p53317-320 Substrate (Ac-QPKK(Ac)-AMC),...
Anwendung: Fluorogenic SIRT1 substrate
CAS 1387005-23-3
MW: 740.9 D
ab 74,00 €
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Z-(L-Arg)-AMC (hydrochloride)
Z-(L-Arg)-AMC (hydrochloride)

Artikelnummer: Cay30797-10

Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H. Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify trypsin, cathepsin B, and cathepsin H activity. AMC displays excitation/emission...
Schlagworte: Bz-Arg-AMC, N-benzoxy-L-Arg-7-amido-4-methylcoumarin, N-benzoyl-L-Arg-AMC, Z-Arg(HCl)AMC,...
Anwendung: Fluorogenic trypsin substrate
CAS 70375-22-3
MW: 502 D
ab 69,00 €
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Z-Lys-OMe (hydrochloride)
Z-Lys-OMe (hydrochloride)

Artikelnummer: Cay30804-1

Z-Lys-OMe is a synthetic intermediate. It has been used in the synthesis of peptide enzyme substrates and lysine cationic surfactants.Formal Name: N2-[(phenylmethoxy)carbonyl]-L-lysine, methyl ester, monohydrochloride. CAS Number: 26348-68-5. Molecular Formula: C15H22N2O4 . HCl. Formula Weight: 330.8. Purity: >98%....
Schlagworte: N2-[(phenylmethoxy)carbonyl]-L-lysine, methyl ester, monohydrochloride
Anwendung: Synthetic intermediate
CAS 26348-68-5
MW: 330.8 D
ab 33,00 €
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