Peptide

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MOTS-c (human)
MOTS-c (human)

Artikelnummer: AG-CP3-0026-M001

Solid lyophilized powder. Soluble in water. Mitochondria-derived peptide (MDP), Promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK), Induces cellular and systemic glucose uptake and improves insulin sensitivity. Shown to prevent diet-induced obesity (DIO) in mice, Potential anti-obesity and anti-aging compound.
Anwendung: Mitochondria-derived peptide, AMPK promoter
CAS 1627580-64-6
MW: 2288,6 D
Reinheit: >95%
Format: Solid
ab 165,00 €
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Z-AEVD-FMK
Z-AEVD-FMK

Artikelnummer: Cay14987-500

Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases. At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its active form, caspase cascade activation, and apoptosis.
Anwendung: Irreversible caspase-10 inhibitor
CAS 1135688-47-9
MW: 610.6 D
Reinheit: >95%
Format: Crystalline Solid
ab 69,00 €
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Ac-LETD-AFC
Ac-LETD-AFC

Artikelnummer: Cay14991-5

Ac-LETD-AFC is a fluorogenic substrate that can be cleaved specifically by caspase-8. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
Anwendung: Fluorogenic Caspase-8 substrate
CAS 210345-02-1
MW: 729.7 D
Reinheit: >95%
Format: Crystalline Solid
ab 78,00 €
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Gly-Pro-pNA (hydrochloride)
Gly-Pro-pNA (hydrochloride)

Artikelnummer: Cay21244-25

Gly-Pro-pNA is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm. DPP IV inactivates the two peptides responsible for a majority of nutrient-stimulated insulin secretion: glucose-dependent insulinotropic polypeptide (GIP) and...
Anwendung: Chromogenic DPP4 substrate
CAS 103213-34-9
MW: 328.8 D
Reinheit: >98%
Format: Crystalline Solid
ab 35,00 €
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AAF-CMK (trifluoroacetate salt)
AAF-CMK (trifluoroacetate salt)

Artikelnummer: Cay14461-5

Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 µM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and...
Anwendung: TPPII inhibitor, Bleomycin hydrolase and aminopeptidase inhibitor
CAS 184901-82-4
MW: 453.8 D
Reinheit: >95%
Format: Crystalline Solid
ab 62,00 €
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Iberiotoxin
Iberiotoxin

Artikelnummer: Cay14608-100

Iberiotoxin, a peptide purified from venom of the scorpion B. tamulus, is a selective blocker of large-conductance calcium ion-activated potassium ion channels (BKCa). In single channel recordings, iberiotoxin can reversibly block outward currents mediated by BKCa in excised membrane patches from bovine aortic smooth muscle with an IC50 value of 250 pM. It is also a...
Anwendung: BKCa blocker
CAS 129203-60-7
MW: 4230.9 D
Reinheit: >95%
Format: Solid
249,00 €
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alpha-Bungarotoxin
alpha-Bungarotoxin

Artikelnummer: Cay16385-1

alpha-Bungarotoxin is a snake venom-derived toxin that irreversibly binds nicotinic acetylcholine receptors (Ki = ~2.5 µM in rat) present in skeletal muscle, blocking action of acetylcholine at the postsynaptic membrane and leading to paralysis. It has been widely used to characterize activity at the neuromuscular junction, which has numerous applications in neuroscience...
Anwendung: Irreversible nicotinic acetylcholine receptor blocker
CAS 11032-79-4
MW: 7984.2 D
Reinheit: >99%
Format: Solid
187,00 €
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Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp
Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp

Artikelnummer: Cay16467-1

Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human neutrophil elastase (kcat/Km = 531 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm, em = 420 nm).
Anwendung: Neutrophil elastase substrate
CAS 824405-61-0
MW: 1456.6 D
Reinheit: >95%
Format: Solid
249,00 €
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Apamin
Apamin

Artikelnummer: Cay17082-500

Apamin is an 18 amino acid peptide toxin found in bee venom. It is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3 (IC50 values are 0.06-0.4, 1-12, and 1-13 nM, respectively). It is ineffective against SK4 at 1 µM. Apamin is used to elucidate the roles of these channels in cells and tissues expressing...
Anwendung: Bee venom toxin, KCa2 blocker
CAS 24345-16-2
MW: 2027.3 D
Reinheit: >95%
Format: Solid
157,00 €
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A-54556B
A-54556B

Artikelnummer: Cay17090-500

A-54556B is a natural acyldepsipeptide (ADEP) antibiotic isolated from the fermentation broth of S. hawaiiensis. Like the closely related ADEP, A-54556A (Cay-15305), A-54556B is effective against Gram-positive bacteria, including penicillin-resistant S. aureus. A-54556B is also effective against many strains of anaerobic bacteria.
Anwendung: Gram-positive bacterial antibiotic
CAS 1629166-56-8
MW: 704.8 D
Reinheit: >95%
Format: Solid
ab 319,00 €
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Enopeptin A
Enopeptin A

Artikelnummer: Cay17092-500

Enopeptin A, originally isolated from a culture broth of Streptomyces sp. RK-1051, is a depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain. It is effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC = 25 µg/ml), and Gram-negative bacteria, including...
Anwendung: Gram-positive bacterial antibiotic
CAS 139601-96-0
MW: 896 D
Reinheit: >95%
Format: Solid
ab 374,00 €
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Micrococcin P1
Micrococcin P1

Artikelnummer: Cay17093-500

Micrococcin P1 is a macrocyclic peptide antibiotic that functions as an acceptor-site-specific inhibitor of ribosomal protein synthesis, effectively preventing the growth of Gram-positive bacteria without affecting that of Gram-negative bacteria.
Anwendung: Gram-positive bacterial antibiotic
CAS 67401-56-3
MW: 1144.4 D
Reinheit: >95%
Format: Solid
ab 374,00 €
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